Phenotypes associated with this allele

• Allele Symbol: Socs1^tm1Jni
• Allele Name: targeted mutation 1, James N Ihle
• Allele ID: MGI:3051623
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs1^tm1Jni/Socs1^tm1Jni	Not Specified	MGI:3051903
ht2	Socs1^tm1Jni/Socs1^+	Not Specified	MGI:3051904
cx3	Ifng^tm1Ts/Ifng^tm1Ts Socs1^tm1Jni/Socs1^tm1Jni	involves: 129S7/SvEvBrd	MGI:3783715

Genotype
MGI:3051903

hm1

• Allelic Composition: Socs1^tm1Jni/Socs1^tm1Jni
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:57475 )

• homozygotes die by 3 weeks of age

hematopoietic system

decreased thymocyte number ( J:57475 )

• numbers begin to decrease within a few days of birth

abnormal T cell differentiation ( J:57475 )

• by day 10 an almost exclusively single positive population of cells

• significant numbers of CD4+ and CD8+ cells in bone marrow

• peripheral splenic T cells are morphologically large blasting cells

• T-cells proliferate in response to Il-2 alone

decreased B cell number ( J:57475 )

• dramatically reduced numbers of B cells in the spleen

immune system

decreased thymocyte number ( J:57475 )

• numbers begin to decrease within a few days of birth

abnormal T cell differentiation ( J:57475 )

• by day 10 an almost exclusively single positive population of cells

• significant numbers of CD4+ and CD8+ cells in bone marrow

• peripheral splenic T cells are morphologically large blasting cells

• T-cells proliferate in response to Il-2 alone

decreased B cell number ( J:57475 )

• dramatically reduced numbers of B cells in the spleen

abnormal cytokine secretion ( J:57475 )

• IFN gamma levels in serum are increased

endocrine/exocrine glands

decreased thymocyte number ( J:57475 )

• numbers begin to decrease within a few days of birth

Genotype
MGI:3051904

ht2

• Allelic Composition: Socs1^tm1Jni/Socs1⁺
• Genetic Background: Not Specified

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91651 )

• 50% of homozygotes die within 3 weeks of dimethylnitrosamine (DMN) while 90% of wild-type controls survive

neoplasm

increased hepatoma incidence ( J:91651 )

• increase in liver tumors induced by diethylnitrosamine

• more of an increase in males than in females

• hyperplastic nodules with mild or no dysplasia

immune system

abnormal cytokine level ( J:91651 )

• plasma levels of various cytokines are increased

• IFN gamma levels increased

• increased TGF beta production

abnormal interleukin level ( J:91651 )

• levels are increased

liver/biliary system

abnormal liver morphology ( J:91651 )

• increased succeptibility to liver fibrosis due to diet or dimethylnitrosamine (DMN)

• liver damage is more severe

increased hepatoma incidence ( J:91651 )

• increase in liver tumors induced by diethylnitrosamine

• more of an increase in males than in females

• hyperplastic nodules with mild or no dysplasia

homeostasis/metabolism

abnormal cytokine level ( J:91651 )

• plasma levels of various cytokines are increased

• IFN gamma levels increased

• increased TGF beta production

abnormal interleukin level ( J:91651 )

• levels are increased

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91651 )

• 50% of homozygotes die within 3 weeks of dimethylnitrosamine (DMN) while 90% of wild-type controls survive

Genotype
MGI:3783715

cx3

• Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts; Socs1^tm1Jni/Socs1^tm1Jni
• Genetic Background: involves: 129S7/SvEvBrd

immune system

increased interleukin-17 secretion ( J:132905 )

• following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells