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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptgestm1Aki
targeted mutation 1, Shizuo Akira
MGI:3051640
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptgestm1Aki/Ptgestm1Aki B6.129P2-Ptgestm1Aki MGI:5517582
hm2
 		Ptgestm1Aki/Ptgestm1Aki involves: 129P2/OlaHsd MGI:3051862
hm3
 		Ptgestm1Aki/Ptgestm1Aki involves: 129X1/SvJ * C57BL/6 MGI:3051863


Genotype
MGI:5517582
hm1
Allelic
Composition		 Ptgestm1Aki/Ptgestm1Aki
Genetic
Background		 B6.129P2-Ptgestm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgestm1Aki mutation (1 available); any Ptges mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

homeostasis/metabolism
edema ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice




Genotype
MGI:3051862
hm2
Allelic
Composition		 Ptgestm1Aki/Ptgestm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgestm1Aki mutation (1 available); any Ptges mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased leukotriene level ( J:92047 )
• PGE2 production is not increased following LPS stimulation; however, endotoxin shock induced lethality is not different from wild-type




Genotype
MGI:3051863
hm3
Allelic
Composition		 Ptgestm1Aki/Ptgestm1Aki
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgestm1Aki mutation (1 available); any Ptges mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:91821 )
• fewer macrophages are found in the peritoneal cavity 4 days after thioglycollate treatment
abnormal inflammatory response ( J:91821 )
• no change in the acetate-induced pain response is seen with LPS stimulation in contrast to the significant increase in pain response seen in wild-type mice
chronic inflammation ( J:91821 )
• decreased formation of granulation tissue and blood vessels is seen in response to an implanted cotton thread
• the severity but not the incidence of collagen antibody-induced arthritis is reduce

homeostasis/metabolism
abnormal prostaglandin level ( J:91821 )
• macrophage PGE2 production is not increased following LPS stimulation

cellular
impaired macrophage chemotaxis ( J:91821 )
• fewer macrophages are found in the peritoneal cavity 4 days after thioglycollate treatment

hematopoietic system
impaired macrophage chemotaxis ( J:91821 )
• fewer macrophages are found in the peritoneal cavity 4 days after thioglycollate treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory