Phenotypes associated with this allele

• Allele Symbol: Gja5^tm1(Gja7)Hvr
• Allele Name: targeted mutation 1, Harold van Rijen
• Allele ID: MGI:3051866
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja5^tm1(Gja7)Hvr/Gja5^tm1(Gja7)Hvr	involves: 129S2/SvPas * C57BL/6	MGI:3051893
hm2	Gja5^tm1(Gja7)Hvr/Gja5^tm1(Gja7)Hvr	involves: 129S2/SvPas * CD-1	MGI:3051892

Genotype
MGI:3051893

hm1

• Allelic Composition: Gja5^tm1(Gja7)Hvr/Gja5^tm1(Gja7)Hvr
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:92018 )

• in an ECG P wave and QRS complex duration are significantly increased suggesting delayed or slower activation of the atria and ventricles

prolonged P wave ( J:92018 )

prolonged QRS complex duration ( J:92018 )

Genotype
MGI:3051892

hm2

• Allelic Composition: Gja5^tm1(Gja7)Hvr/Gja5^tm1(Gja7)Hvr
• Genetic Background: involves: 129S2/SvPas * CD-1

cardiovascular system

abnormal impulse conducting system conduction ( J:92018 )

• the conduction velocity in the left atrium is significantly slower

• activation time of the right ventricle is significantly increased

abnormal heart electrocardiography waveform feature ( J:92018 )

• in an ECG P wave and QRS complex duration are significantly increased suggesting delayed or slower activation of the atria and ventricles

prolonged P wave ( J:92018 )

prolonged QRS complex duration ( J:92018 )