Analysis Tools
mortality/aging
|
• partial postnatal lethality, as only 4.6% of pups at 2 weeks of age are mutants
|
growth/size/body
|
• smaller at birth
|
|
• neonatal weights are decreased by 11.6%
|
cardiovascular system
|
• 3 of 5 neonates exhibit a variety of coronary abnormalities
|
|
• the right ventricle appears more heavily trabeculated at E15.5
|
|
• exhibit a late phase of cellular delamination from the dorsal and lateral neural tube, a markedly increased abundance of neuroepithelium-derived cells outside of the neural tube and an excess of such cells infiltrating the heart and infundibulum
|
|
• neonates exhibit grossly misshapen right ventricle outflow tract (RVOT), with large infundibular bulges seen bilaterally flanking the outflow tract
• RVOT is first observed at E15.5, with the right ventricle appearing more heavily trabeculated
• outflow tracts appear dilated and more densly trabeculated
• regions of the infundibular wall showing thinning
|
|
• the right ventricular wall is slightly thinner
|
nervous system
|
• exhibit a late phase of cellular delamination from the dorsal and lateral neural tube, a markedly increased abundance of neuroepithelium-derived cells outside of the neural tube and an excess of such cells infiltrating the heart and infundibulum
|
muscle
|
• the right ventricle appears more heavily trabeculated at E15.5
|
