Phenotypes associated with this allele

• Allele Symbol: Cckar^tm1Kpn
• Allele Name: targeted mutation 1, Alan S Kopin
• Allele ID: MGI:3051882
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cckar^tm1Kpn/Cckar^tm1Kpn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3789903
hm2	Cckar^tm1Kpn/Cckar^tm1Kpn	involves: 129S/SvEv	MGI:3052340
hm3	Cckar^tm1Kpn/Cckar^tm1Kpn	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:3052339

Genotype
MGI:3789903

hm1

• Allelic Composition: Cckar^tm1Kpn/Cckar^tm1Kpn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:96891 )

• the increased number of GnRH-1 neurons found in the forebrain of E14.5 embryos is indicative of an accelerated neuronal migration from the nose towards the brain during development

abnormal forebrain morphology ( J:96891 )

• the forebrain of E14.5 embryos contains 16-20% more gonadotropin-releasing hormone-1 neuroendocrine (GnRH-1) neurons than in wild-type embryos

cellular

abnormal neuronal migration ( J:96891 )

• the increased number of GnRH-1 neurons found in the forebrain of E14.5 embryos is indicative of an accelerated neuronal migration from the nose towards the brain during development

Genotype
MGI:3052340

hm2

• Allelic Composition: Cckar^tm1Kpn/Cckar^tm1Kpn
• Genetic Background: involves: 129S/SvEv

digestive/alimentary system

increased intestinal cholesterol absorption ( J:91998 )

• percent cholesterol absorption values are increased in mutants on a lithogenic diet compared to wild-type mice

abnormal small intestinal transit time ( J:91998 )

• small intestinal transit time is increased in mutants on both normal chow and lithogenic diets

homeostasis/metabolism

increased intestinal cholesterol absorption ( J:91998 )

• percent cholesterol absorption values are increased in mutants on a lithogenic diet compared to wild-type mice

abnormal bile salt homeostasis ( J:91998 )

• the bile salt pool is larger in mutants on a lithogenic diet compared to wild-type mice

abnormal cholesterol homeostasis ( J:91998 )

• increased cholesterol is seen in the gall bladder and hepatic bile in mutants on a lithogenic diet compared to wild-type mice

liver/biliary system

increased gallbladder volume ( J:91998 )

• on a lithogenic diet gall bladder volumes are greater in mutants compared to wild-type mice

gallstones ( J:91998 )

• on a lithogenic diet significantly more gallstones are found in mutants

abnormal bile composition ( J:91998 )

• the cholesterol content of the bile salts is increased in mutants on a lithogenic diet compared to wild-type mice

endocrine/exocrine glands

increased gallbladder volume ( J:91998 )

• on a lithogenic diet gall bladder volumes are greater in mutants compared to wild-type mice

growth/size/body

increased gallbladder volume ( J:91998 )

• on a lithogenic diet gall bladder volumes are greater in mutants compared to wild-type mice

Genotype
MGI:3052339

hm3

• Allelic Composition: Cckar^tm1Kpn/Cckar^tm1Kpn
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

nervous system

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

abnormal rostral migratory stream morphology ( J:132859 )

• fewer proliferating cells are found in the subventricular zone and migratory rostral stream compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

abnormal postnatal subventricular zone morphology ( J:132859 )

• fewer proliferating cells are found in the subventricular zone leading to fewer migrating neuroblasts compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

decreased neuronal precursor cell number ( J:132859 )

• fewer proliferating cells are found in the subventricular zone and migratory rostral stream compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

liver/biliary system

gallstones ( J:53711 )

• mutants are prone to developing gallstones

behavior/neurological

abnormal food intake ( J:53711 )

• basal food and water intake are normal however treatment with CCK-8 fails to inhibit food intake

• blood glucose levels and pancreatic beta cell morphology are also normal

craniofacial

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

respiratory system

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

growth/size/body

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice