mortality/aging
• homozygotes begin to die at E12.5 and all are dead by birth
|
• homozygotes begin to die at E12.5 and all are dead by birth
|
cardiovascular system
• walls of heart are thinner than normal
|
embryo
growth/size/body
hematopoietic system
• erythroblasts in the fetal liver are increased in size
|
• decreased number of erythroblasts in the fetal liver
• half normal number of red blood cells in the periphery
|
• hematocrit half normal
|
• hemoglobin content of peripheral blood half normal
|
liver/biliary system
small liver
(
J:90889
)
• fetal livers about 1/3 normal size
• decreased numbers of erythroblasts in the liver
• a large fraction of fetal liver cells are apoptotic
|