Phenotypes associated with this allele

• Allele Symbol: Ciapin1^tm1Yzka
• Allele Name: targeted mutation 1, Yuzuru Kanakura
• Allele ID: MGI:3051894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ciapin1^tm1Yzka/Ciapin1^tm1Yzka	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3052333

Genotype
MGI:3052333

hm1

• Allelic Composition: Ciapin1^tm1Yzka/Ciapin1^tm1Yzka
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:90889 )

• homozygotes begin to die at E12.5 and all are dead by birth

embryonic lethality during organogenesis, incomplete penetrance ( J:90889 )

• homozygotes begin to die at E12.5 and all are dead by birth

cardiovascular system

abnormal heart morphology ( J:90889 )

• walls of heart are thinner than normal

embryo

decreased embryo size ( J:90889 )

growth/size/body

decreased embryo size ( J:90889 )

hematopoietic system

abnormal erythrocyte morphology ( J:90889 )

• erythroblasts in the fetal liver are increased in size

decreased erythrocyte cell number ( J:90889 )

• decreased number of erythroblasts in the fetal liver

• half normal number of red blood cells in the periphery

decreased hematocrit ( J:90889 )

• hematocrit half normal

decreased hemoglobin content ( J:90889 )

• hemoglobin content of peripheral blood half normal

liver/biliary system

small liver ( J:90889 )

• fetal livers about 1/3 normal size

• decreased numbers of erythroblasts in the liver

• a large fraction of fetal liver cells are apoptotic