All Phenotypes Ubash3a<tm1Jni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ubash3a^tm1Jni/Ubash3a^tm1Jni	Not Specified	MGI:3052002
cx2	Ubash3b^tm1Jni/Ubash3b^tm1Jni Ubash3a^tm1Jni/Ubash3a^tm1Jni	Not Specified	MGI:3052004
cx3	Cblb^tm1Hua/Cblb^tm1Hua Ubash3b^tm1Jni/Ubash3b^tm1Jni Ubash3a^tm1Jni/Ubash3a^tm1Jni	Not Specified	MGI:3052005

Allelic Composition	Ubash3a^tm1Jni/Ubash3a^tm1Jni
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubash3a^tm1Jni mutation (0 available); any Ubash3a mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89761 )

• homozygotes are viable and healthy with no abnormalities detected in any of the hematopoietic lineages

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is increased 10 fold in response to antigen compared to wild-type mice

• this increased proliferation is more pronounced than in Cblb^tm1Hua homozygotes

increased mature B cell number ( J:89761 )

• the percentage of mature IgM^-IgD⁺ splenic and peripheral lymph node B cells is increased and the percentage of less mature IgM⁺IgD^- B cells is decreased

increased splenocyte number ( J:89761 )

• the total number of splenocytes is increased 30-50% in mutants compared to wild-type mice

immune system

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is increased 10 fold in response to antigen compared to wild-type mice

• this increased proliferation is more pronounced than in Cblb^tm1Hua homozygotes

increased mature B cell number ( J:89761 )

• the percentage of mature IgM^-IgD⁺ splenic and peripheral lymph node B cells is increased and the percentage of less mature IgM⁺IgD^- B cells is decreased

increased splenocyte number ( J:89761 )

• the total number of splenocytes is increased 30-50% in mutants compared to wild-type mice

abnormal cytokine secretion ( J:89761 )

• antigen stimulated cytokine secretion is increased in cultured mutant thymocytes compared to wild-type cultures

increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )

• the incidence and severity of experimental autoimmune encephalomyelitis is markedly increased with 20% of mutants dying compared to 4% of wild-type mice

• double homozygotes are also more susceptible to this disease than Cblb^tm1Hua homozygotes

cellular

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is increased 10 fold in response to antigen compared to wild-type mice

• this increased proliferation is more pronounced than in Cblb^tm1Hua homozygotes

Allelic Composition	Cblb^tm1Hua/Cblb^tm1Hua Ubash3b^tm1Jni/Ubash3b^tm1Jni Ubash3a^tm1Jni/Ubash3a^tm1Jni
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblb^tm1Hua mutation (0 available); any Cblb mutation (58 available)
Ubash3a^tm1Jni mutation (0 available); any Ubash3a mutation (33 available)
Ubash3b^tm1Jni mutation (0 available); any Ubash3b mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes or Cblb^tm1Hua homozygotes

increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )

• the incidence and severity of experimental autoimmune encephalomyelitis is increased similar to the increase seen in Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes

hematopoietic system

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes or Cblb^tm1Hua homozygotes

cellular

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes or Cblb^tm1Hua homozygotes

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