Phenotypes associated with this allele

• Allele Symbol: Tg(VIM-Tag)3Pau
• Allele Name: transgene insertion 3, Denise Pauline
• Allele ID: MGI:3052038
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(VIM-Tag)3Pau/0	either: (involves: C57BL/6 * CBA * SJL/J) or (involves: C57BL/6 * SJL/J)	MGI:3720109
tg2	Tg(VIM-Tag)3Pau/0	involves: C57BL/6 * SJL/J	MGI:3720107

Genotype
MGI:3720109

tg1

• Allelic Composition: Tg(VIM-Tag)3Pau/0
• Genetic Background: either: (involves: C57BL/6 * CBA * SJL/J) or (involves: C57BL/6 * SJL/J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92226 )

• transgenics that survive beyond 3 weeks die between 60 and 90 days of age

postnatal lethality, incomplete penetrance ( J:92226 )

• one third of the transgenic mice die within 2-3 weeks of birth

renal/urinary system

glomerulonephritis ( J:92226 )

• exhibit diffuse hypercellular glomeruli and tubule dilation characteristic of proliferative glomerulonephritis

dilated renal tubule ( J:92226 )

nervous system

abnormal cerebral cortex morphology ( J:92226 )

• infiltration of the cortex by glial cells is seen

immune system

glomerulonephritis ( J:92226 )

• exhibit diffuse hypercellular glomeruli and tubule dilation characteristic of proliferative glomerulonephritis

Genotype
MGI:3720107

tg2

• Allelic Composition: Tg(VIM-Tag)3Pau/0
• Genetic Background: involves: C57BL/6 * SJL/J

hematopoietic system

enlarged thymus ( J:91542 )

thymus hyperplasia ( J:91542 )

• at 4-6 weeks of age the thymus contains about 20-fold more cells than wild-type

increased double-negative T cell number ( J:91542 )

• the total number of DN cells is increased 115-fold

immune system

enlarged thymus ( J:91542 )

thymus hyperplasia ( J:91542 )

• at 4-6 weeks of age the thymus contains about 20-fold more cells than wild-type

increased double-negative T cell number ( J:91542 )

• the total number of DN cells is increased 115-fold

endocrine/exocrine glands

enlarged thymus ( J:91542 )

thymus hyperplasia ( J:91542 )

• at 4-6 weeks of age the thymus contains about 20-fold more cells than wild-type