Phenotypes associated with this allele

• Allele Symbol: Myh10^tm3Rsad
• Allele Name: targeted mutation 3, Robert S Adelstein
• Allele ID: MGI:3052104
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh10^tm3Rsad/Myh10^tm3Rsad	involves: 129S6/SvEvTac * C57BL/6	MGI:3052311

Genotype
MGI:3052311

hm1

• Allelic Composition: Myh10^tm3Rsad/Myh10^tm3Rsad
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92081 )

• most mutant pups die within two days of birth with less than 10% surviving to P15 (only 1 survived to P20)

behavior/neurological

ataxia ( J:92081 )

• ataxia manifests as a wide gait and impaired balance

impaired balance ( J:92081 )

• mutants are unable to balance on a rotorod

cardiovascular system

abnormal heart ventricle morphology ( J:92230 )

• at E12.5 the percentage of binucleated cells is increased to 23% from 1% in wild-type and the size of the myocytes is increased

nervous system

decreased neuronal migration ( J:92081 )

• granule cells migration out of the EGL is slower in mutants compared to wild-type

• pontine neurons fail to reach the basilar pons at P0 and are instead found to accumulate along with reticular neurons under the pial surfarce in the lateral posterior area of the medulla

• abnormal accumulation of neurons from the posterior extramural migratory stream is also seen

hydrocephaly ( J:92081 , J:112536 )

• progressive hydroencephaly is seen by P3 (J:92081)

• mice show severe hydroencephaly (J:112536)

abnormal fourth ventricle morphology ( J:112536 )

• mice show protrusion of facial neurons into fourth ventricle

abnormal cerebral cortex morphology ( J:92081 )

• at P12 a distorted cerebral cortex is seen

abnormal cerebellum morphology ( J:92081 )

abnormal cerebellar foliation ( J:92081 )

• at P0 fissures are shallower than normal and those at folia II, III, VII, and VIII are absent

• at P8 fissures in the anterior and middle portion are shallower or absent while those in the posterior portion look almost normal

abnormal cerebellum external granule cell layer morphology ( J:92081 )

• at P0 the EGL is thinner than normal however by P8 the thickness is comparable and by P15 the EGL is more prominent compared to wild-type

abnormal Purkinje cell morphology ( J:92081 )

• cerebellar Purkinje cells are smaller and irregularly aligned

decreased Purkinje cell size ( J:92081 )

abnormal cerebellar granule layer morphology ( J:92081 )

• at P8 the mutant IGL is about half the thickness of wild-type

abnormal cerebellar molecular layer ( J:92081 )

• a reduced number of migrating granule cells are seen at P8

small cerebellum ( J:92081 )

• at P12 a small cerebellum is seen

abnormal facial nerve morphology ( J:92081 )

• at P0 the facial neurons are diminished with most failing to reach their normal location and instead forming a mass the protrudes into the fourth ventricle

cellular

decreased neuronal migration ( J:92081 )

• granule cells migration out of the EGL is slower in mutants compared to wild-type

• pontine neurons fail to reach the basilar pons at P0 and are instead found to accumulate along with reticular neurons under the pial surfarce in the lateral posterior area of the medulla

• abnormal accumulation of neurons from the posterior extramural migratory stream is also seen

growth/size/body

growth/size/body region phenotype ( J:245570 )

N • embryos DO NOT exhibit defects in ventral body wall closure or midline fusion