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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Disp1tm1Amc
targeted mutation 1, Andrew P McMahon
MGI:3052133
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Disp1tm1Amc/Disp1tm1Amc involves: 129X1/SvJ MGI:3052722
ht2
 		Disp1icb/Disp1tm1Amc involves: 129X1/SvJ * C57BL/6J MGI:3052725
cn3
 		Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129X1/SvJ * C57BL/6J MGI:3054017
cx4
 		Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3052724
cx5
 		Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+ 		involves: 129X1/SvJ * C57BL/6J MGI:3052728


Genotype
MGI:3052722
hm1
Allelic
Composition		 Disp1tm1Amc/Disp1tm1Amc
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:92058 )
• die at birth, difficulty breathing

growth/size/body
abnormal facial morphology ( J:92058 )
• mild midline facial defects involving the nose and upper jaw
absent upper incisors ( J:92058 )
• loss of upper incisors
philtrum hypoplasia ( J:92058 )
• hypoplastic philtrum
absent primary palate ( J:92058 )
• loss of primary palate
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs

craniofacial
abnormal facial morphology ( J:92058 )
• mild midline facial defects involving the nose and upper jaw
absent upper incisors ( J:92058 )
• loss of upper incisors
philtrum hypoplasia ( J:92058 )
• hypoplastic philtrum
absent primary palate ( J:92058 )
• loss of primary palate
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs

respiratory system
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs
abnormal nasopharynx morphology ( J:92058 )
• nasopharyngeal airway narrowed or closed
respiratory distress ( J:92058 )
• difficulty breathing at birth leading to death

endocrine/exocrine glands

vision/eye
ocular hypotelorism ( J:92058 )
• eyes positioned near the midline

nervous system
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs
abnormal neuron specification ( J:92058 )
• 40% reduction of progenitor V3 population

skeleton
absent upper incisors ( J:92058 )
• loss of upper incisors

digestive/alimentary system
absent primary palate ( J:92058 )
• loss of primary palate




Genotype
MGI:3052725
ht2
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
absent primary palate ( J:92058 )
• loss of primary palate

craniofacial
abnormal basisphenoid bone morphology ( J:92058 )
• misshapen or absent
absent basisphenoid bone ( J:92058 )
• misshapen or absent
abnormal occipital bone morphology ( J:92058 )
• misshapen or absent
absent occipital bone ( J:92058 )
• misshapen or absent
abnormal viscerocranium morphology ( J:92058 )
• loss of primary palate, premaxillary and nasal components
abnormal frontal bone morphology ( J:92058 )
• severe losses of frontal component
absent upper incisors ( J:92058 )
• loss of upper incisors
absent primary palate ( J:92058 )
• loss of primary palate
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs

endocrine/exocrine glands
absent pituitary gland ( J:92058 )
• failed to develop

respiratory system
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs
abnormal nasopharynx morphology ( J:92058 )
• nasopharyngeal airway narrowed or closed

skeleton
abnormal basisphenoid bone morphology ( J:92058 )
• misshapen or absent
absent basisphenoid bone ( J:92058 )
• misshapen or absent
abnormal occipital bone morphology ( J:92058 )
• misshapen or absent
absent occipital bone ( J:92058 )
• misshapen or absent
abnormal viscerocranium morphology ( J:92058 )
• loss of primary palate, premaxillary and nasal components
abnormal frontal bone morphology ( J:92058 )
• severe losses of frontal component
absent upper incisors ( J:92058 )
• loss of upper incisors
delayed chondrocyte differentiation ( J:92058 )
• delayed differentiation in the cervical region

nervous system
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs
absent pituitary gland ( J:92058 )
• failed to develop

growth/size/body
abnormal head morphology ( J:92058 )
• severe midline facial defects by E10.5
absent upper incisors ( J:92058 )
• loss of upper incisors
absent primary palate ( J:92058 )
• loss of primary palate
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs




Genotype
MGI:3054017
cn3
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
oligodactyly ( J:92504 )
• digit 2 is absent, all other digits are present




Genotype
MGI:3052724
cx4
Allelic
Composition		 Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:92058 )
• viable fertile, and outwardly normal

nervous system
nervous system phenotype ( J:92058 )
N
• normal floor plate and progenitor/precursor neuron patterning




Genotype
MGI:3052728
cx5
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Shhtm1Amc mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
failure of heart looping ( J:92058 )
• no heart looping but normal embryo turning

nervous system
abnormal neuron specification ( J:92058 )
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors

craniofacial
proboscis ( J:92058 )
• extreme proboscis-like nasal process

growth/size/body
proboscis ( J:92058 )
• extreme proboscis-like nasal process

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
holoprosencephaly 3 DOID:0110875 OMIM:142945
 J:92058




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory