Phenotypes associated with this allele

• Allele Symbol: Hr^tm1Cct
• Allele Name: targeted mutation 1, Catherine C Thompson
• Allele ID: MGI:3052135
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hr^tm1Cct/Hr^tm1Cct	involves: 129	MGI:3715283
hm2	Hr^tm1Cct/Hr^tm1Cct	involves: 129/Sv * C57BL/6	MGI:3052421
cx3	Hr^tm1Cct/Hr^tm1Cct Tg(KRT14-Hr)551Cct/0	involves: 129/Sv * C57BL/6 * SJL	MGI:3715284

Genotype
MGI:3715283

hm1

• Allelic Composition: Hr^tm1Cct/Hr^tm1Cct
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

alopecia ( J:102493 )

• BY P22, mice exhibit hair loss

abnormal skin morphology ( J:102493 )

• abnormal epidermal structures (utricles) form by P22; skin is grossly abnormal

Genotype
MGI:3052421

hm2

• Allelic Composition: Hr^tm1Cct/Hr^tm1Cct
• Genetic Background: involves: 129/Sv * C57BL/6

integument

alopecia ( J:92053 )

• first postnatal hair coat grows normally

• hair loss begins around age 18 and starts at the head, proceeding caudally in a scattered pattern

• hair follicles fail to regenerate

dilated piliary canal ( J:92053 )

• by day 12, pilary canal widens to form a utricle

abnormal skin morphology ( J:92053 )

dermal cyst ( J:92053 )

• small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant

wrinkled skin ( J:92053 )

• skin becomes progressively more wrinkled with age

skin hyperplasia ( J:92053 )

• increased cell proliferation in epidermis and utricles

growth/size/body

dermal cyst ( J:92053 )

• small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant

Genotype
MGI:3715284

cx3

• Allelic Composition: Hr^tm1Cct/Hr^tm1Cct; Tg(KRT14-Hr)551Cct/0
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

integument

alopecia ( J:102493 )

• by P22, mice exhibit hair loss; however mice regenerate hair and display thick fur by P28

abnormal hair follicle morphology ( J:102493 )

• at P22, follicle morphology is abnormal; by P28, regenerated hair follicles resemble wild-type follicles

abnormal skin morphology ( J:102493 )

• abnormal epidermal structures (utricles) form by P22