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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TcrLCMV)1Aox
transgene insertion 1, Annette Oxenius
MGI:3052138
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(TcrLCMV)1Aox/? C57BL/6-Tg(TcrLCMV)1Aox MGI:3052145


Genotype
MGI:3052145
tg1
Allelic
Composition
Tg(TcrLCMV)1Aox/?
Genetic
Background
C57BL/6-Tg(TcrLCMV)1Aox
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcrLCMV)1Aox mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• virtual absence of double positive cells
• increased numbers of CD4+CD8- cells
• more than 95% of peripheral CD4+ T cells express transgene
• the ratio of CD4+ to CD8+ T cells is 27:1 compared to 1.8:1 in wild-type mice
• the number of CD4-CD8+ cells is decreased
• GP specific IgG produced under stimulus
• severely impaired cytotoxic T cell response

hematopoietic system
• virtual absence of double positive cells
• increased numbers of CD4+CD8- cells
• more than 95% of peripheral CD4+ T cells express transgene
• the ratio of CD4+ to CD8+ T cells is 27:1 compared to 1.8:1 in wild-type mice
• the number of CD4-CD8+ cells is decreased
• GP specific IgG produced under stimulus
• severely impaired cytotoxic T cell response





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory