Phenotypes associated with this allele

• Allele Symbol: Zic5^tm1Jaru
• Allele Name: targeted mutation 1, Jun Aruga
• Allele ID: MGI:3052154
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zic5^tm1Jaru/Zic5^tm1Jaru	involves: 129P2/OlaHsd * C57BL/6J	MGI:3052307

Genotype
MGI:3052307

hm1

• Allelic Composition: Zic5^tm1Jaru/Zic5^tm1Jaru
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92220 )

• most mutants die by 2 months of age

postnatal lethality ( J:92220 )

• fewer than expected mutants are found after birth (P0 - P3)

behavior/neurological

abnormal posture ( J:92220 )

• abnormal posture associated with hydrocephalus is seen by 1 week of age in a few mutants (4/16)

abnormal gait ( J:92220 )

• abnormal gait associated with hydrocephalus is seen by 1 week of age in a few mutants (4/16)

craniofacial

abnormal incisor morphology ( J:92220 )

• a solitary incisor at the midline is seen in 4 out of 19 mutants

small mandible ( J:92220 )

• the mandible is smaller than normal and the two halves are abnormally fused

small premaxilla ( J:92220 )

• the premaxilla are slightly reduced in size

growth/size/body

abnormal incisor morphology ( J:92220 )

• a solitary incisor at the midline is seen in 4 out of 19 mutants

decreased body weight ( J:92220 )

• average body weight at 3 weeks is 32% that of wild-type littermates

skeleton

abnormal incisor morphology ( J:92220 )

• a solitary incisor at the midline is seen in 4 out of 19 mutants

small mandible ( J:92220 )

• the mandible is smaller than normal and the two halves are abnormally fused

small premaxilla ( J:92220 )

• the premaxilla are slightly reduced in size

nervous system

open neural tube ( J:92220 )

• at E10.5 the cranial neural tube remains open

hydrocephaly ( J:92220 )

• hydroencephaly is seen in 4 out of 16 mutants

abnormal basal ganglion morphology ( J:92220 )

• the basal ganglia are disorganized

abnormal diencephalon morphology ( J:92220 )

• the diencephalon is displaced anteriorly

abnormal hippocampus morphology ( J:92220 )

• the hippocampus is disorganized

abnormal cerebral cortex morphology ( J:92220 )

• at E17.5 the cerebral cortex is disorganized

exencephaly ( J:92220 )

• at E13 - 18 in about 15% of mutants exencephaly is seen in the forebrain, midbrain, and hindbrain regions

embryo

open neural tube ( J:92220 )

• at E10.5 the cranial neural tube remains open