Phenotypes associated with this allele

• Allele Symbol: Ezr^tm1Aim
• Allele Name: targeted mutation 1, Andrea I McClatchey
• Allele ID: MGI:3052158
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ezr^tm1Aim/Ezr^tm1Aim	involves: 129S4/SvJae * C57BL/6J	MGI:3052173

Genotype
MGI:3052173

hm1

• Allelic Composition: Ezr^tm1Aim/Ezr^tm1Aim
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92210 )

• homozygotes fail to thrive and die before weaning

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:92210 )

• villi fuse to form abnormal cauliflower shaped aggregations in which the cells remain stratified rather than becoming to columnar

• abnormal villi can be seen by E15.5

• the morphological complexity of these aggregations increases as mutants age

• microvilli are short, thick, and nonuniform compared to wild-type