Phenotypes associated with this allele

• Allele Symbol: Ciita^tm2Wrth
• Allele Name: targeted mutation 2, Walter Reith
• Allele ID: MGI:3052223
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ciita^tm2Wrth/Ciita^tm2Wrth	B6.129P2-Ciita^tm2Wrth	MGI:3696681
hm2	Ciita^tm2Wrth/Ciita^tm2Wrth	involves: 129P2/OlaHsd * C57BL/6	MGI:3052466

Genotype
MGI:3696681

hm1

• Allelic Composition: Ciita^tm2Wrth/Ciita^tm2Wrth
• Genetic Background: B6.129P2-Ciita^tm2Wrth

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:117111 )

N • mice do not show decreased levels of soluble MHC-II, suggesting that B cells, dendritic cells and stromal cells do not contribute significantly to circulating levels of soluble I-A^b

Genotype
MGI:3052466

hm2

• Allelic Composition: Ciita^tm2Wrth/Ciita^tm2Wrth
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:92170 )

• reduced numbers of CD4+ T cells

• results in lymphopenia

abnormal immunoglobulin level ( J:92170 )

• no antibody response to T-cell dependent antigens

immune system

decreased CD4-positive, alpha-beta T cell number ( J:92170 )

• reduced numbers of CD4+ T cells

• results in lymphopenia

abnormal immunoglobulin level ( J:92170 )

• no antibody response to T-cell dependent antigens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
MHC class II deficiency		DOID:5812	OMIM:209920	J:92170