All Phenotypes Rtel1<tm1Pml> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:91351 )

• mutant embryos die around E11.5

abnormal placenta vasculature ( J:91351 )

• at E8.5 mutant placentas lack fetal blood vessels

abnormal heart ventricle morphology ( J:91351 )

• at E9.5-10.5 the ventricles of the heart are laterally displaced

hemopericardium ( J:91351 )

• at E9.5-10.5 the pericardium is filled with blood

hematoma ( J:91351 )

• subcutaneous hematomas are seen at various sites on the body

abnormal cell differentiation ( J:91351 )

• under conditions that induce differentiation few mutant embryonic stem cells differentiate and almost all proliferation is stopped

• telomere length is significantly shorter and chromosomal abnormalities are seen in differentiating cells

abnormal placenta vasculature ( J:91351 )

• at E8.5 mutant placentas lack fetal blood vessels

embryonic growth retardation ( J:91351 )

• embryos become progressively more growth retarded at E9.5 and E10.5

decreased embryo size ( J:91351 )

• mutant embryos are smaller than wild-type littermates by E8.5

abnormal head paraxial mesoderm morphology ( J:91351 )

• fewer cells are seen in the cranial paraxial mesoderm

abnormal cephalic neural fold morphology ( J:91351 )

• at E8.5 smaller head folds are seen

abnormal neural tube morphology ( J:91351 )

• at E9.5 and E10.5 closure defects in and an irregularly shaped neural tube with poor epithelial organization and fewer cells are seen

enlarged floor plate ( J:91351 )

• at E8.5, a wider floor plate is is found in the neural groove

abnormal neural crest cell morphology ( J:91351 )

• fewer and abnormally packed neural crest cells are seen in the dorsal root ganglia

incomplete rostral neuropore closure ( J:91351 )

• E9.5 and E10.5 embryos show closure defects of the fore- and midbrain

decreased trophoblast giant cell number ( J:91351 )

• at E8.5 the trophoblast cell layer is thinner in the chorionic labyrinth

small ectoplacental cone ( J:91351 )

• at E8.5 the ectoplacental cone is significantly smaller

small allantois ( J:91351 )

• at E8.5 the bulbous allantois is smaller compared to wild-type littermates

failure of chorioallantoic fusion ( J:91351 )

• at E9.5-10.5 the bulbous allantois fails to fuse with the chorion of the placenta