About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dusp10tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3052343
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dusp10tm1Flv/Dusp10tm1Flv involves: 129S6/SvEvTac MGI:3052357


Genotype
MGI:3052357
hm1
Allelic
Composition		 Dusp10tm1Flv/Dusp10tm1Flv
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp10tm1Flv mutation (0 available); any Dusp10 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased activated T cell number ( J:92104 )
• enhanced APC priming in response to LPS stimulation
decreased T cell proliferation ( J:92104 )
• in response to antigen
increased susceptibility to type I hypersensitivity reaction ( J:92104 )
• fatal response to secondary LCMV challenge
increased interferon-gamma secretion ( J:92104 )
• antigen stimulation of Th1 and Th2 cells produced increased levels of IFNG
• anti-CD3 stimulated Th1 and Th2 cells produced increased levels of IFNG
abnormal interleukin secretion ( J:92104 )
• anti-CD3 stimulated Th1 and Th2 cells produced increased levels of IL4
• LPS stimulated antigen presenting cells produce increased levels of IL2
• macrophages produced increased levels of IL6 in response to LPS stimulation or bacterial infection
increased tumor necrosis factor secretion ( J:92104 )
• antigen stimulation of Th1 and Th2 cells produced increased levels of TNFA
• macrophages produced increased levels of TNFA in response to LPS stimulation or bacterial infection
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:92104 )
• decreased incidence and severity of disease in response to EAE induction

hematopoietic system
decreased T cell proliferation ( J:92104 )
• in response to antigen
increased activated T cell number ( J:92104 )
• enhanced APC priming in response to LPS stimulation

cellular
decreased T cell proliferation ( J:92104 )
• in response to antigen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory