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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Luc)Kael
targeted mutation 1, William G Kaelin
MGI:3052356
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * FVB/NJ MGI:3052358
cn2
 		Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+
Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Krastm4Tyj/Kras+
Tg(Scgb1a1-rtTA)1Jaw/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4999988


Genotype
MGI:3052358
ht1
Allelic
Composition		 Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Luc)Kael mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:92043 )
• mice heterozygous for this targeted reporter gene are viable, fertile and exhibit no gross physical or behavioral abnormalities




Genotype
MGI:4999988
cn2
Allelic
Composition		 Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+
Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Krastm4Tyj/Kras+
Tg(Scgb1a1-rtTA)1Jaw/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(Luc)Kael mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Scgb1a1-rtTA)1Jaw mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171191 )
• mice treated with a cre-expressing adenovirus and treated with doxycycline exhibit reduced survival compared with control mice

neoplasm
increased tumor incidence ( J:171191 )
• mice treated with a cre-expressing adenovirus and treated with doxycycline exhibit increased tumor incidence (size and number) in the lungs with rare noninvasive lung adenomas compared with control mice
• however, mice treated with a cre-expressing adenovirus and treated with doxycycline exhibit tumor regression after doxycycline removal
increased lung adenoma incidence ( J:171191 )
• in mice treated with a cre-expressing adenovirus and treated with doxycycline

respiratory system
increased lung adenoma incidence ( J:171191 )
• in mice treated with a cre-expressing adenovirus and treated with doxycycline
respiratory distress ( J:171191 )
• rapid shallow breathing in mice treated with a cre-expressing adenovirus and treated with doxycycline

growth/size/body
cachexia ( J:171191 )
• in mice treated with a cre-expressing adenovirus and treated with doxycycline




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory