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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmbim6Gt1Jcre
gene trap 1, John C Reed
MGI:3052422
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmbim6Gt1Jcre/Tmbim6Gt1Jcre Not Specified MGI:3052481


Genotype
MGI:3052481
hm1
Allelic
Composition		 Tmbim6Gt1Jcre/Tmbim6Gt1Jcre
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmbim6Gt1Jcre mutation (0 available); any Tmbim6 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:91831 )
• injection of tunicamycin, an inducer of cell death through ER stress pathways, results in increased necrosis in the cortical areas of the kidneys and apoptosis in hippocampal neurons compared to wild-type mice
• MEFs and primary cultures of hepatocytes and cortical neurons from homozygous mutants also show increased sensitivity to tunicamycin and thapsigargin in vitro
increased susceptibility to ischemic brain injury ( J:91831 )
• infarct volumes are increased following transient middle cerebral artery occlusion in mutants compared to wild-type mice

nervous system
increased susceptibility to ischemic brain injury ( J:91831 )
• infarct volumes are increased following transient middle cerebral artery occlusion in mutants compared to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory