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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pres-cre)1Jnz
transgene insertion 1, Jian Zuo
MGI:3052546
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Thrbtm1Df/Thrbtm1Mkni
Tg(Pres-cre)1Jnz/0 		involves: 129S1/Sv * C57BL/6J * FVB/NJ MGI:3836781


Genotype
MGI:3836781
cn1
Allelic
Composition		 Thrbtm1Df/Thrbtm1Mkni
Tg(Pres-cre)1Jnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pres-cre)1Jnz mutation (0 available)
Thrbtm1Df mutation (1 available); any Thrb mutation (41 available)
Thrbtm1Mkni mutation (0 available); any Thrb mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal cochlear inner hair cell physiology ( J:145941 )
• voltage activated K+ currents are absent from inner hair cells
increased or absent threshold for auditory brainstem response ( J:145941 )
• significant increase in ABR thresholds at frequencies less than 8 kHz

nervous system
abnormal cochlear inner hair cell physiology ( J:145941 )
• voltage activated K+ currents are absent from inner hair cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory