Phenotypes associated with this allele

• Allele Symbol: Tg(H2-Ea^d)12Lt
• Allele Name: transgene insertion 12, Edward H Leiter
• Allele ID: MGI:3052550
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(H2-Ea^d)12Lt/0	NOD/ShiLt-Tg(H2-Ea^d)12Lt	MGI:3618813

Genotype
MGI:3618813

tg1

• Allelic Composition: Tg(H2-Ea^d)12Lt/0
• Genetic Background: NOD/ShiLt-Tg(H2-Ea^d)12Lt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:36435 )

• at 40 weeks, pancreata of females show widespread invasive and destructive insulits, while males exhibit mild insulitis

• transgenic mice developed diabetes at a higher incidence when injected with cyclophosphamide at 11 weeks compared to 6 weeks of age, indicating that insulitis is increasing in severity with age

decreased interferon-gamma secretion ( J:36435 )

• GAD65-reactive T cells from transgenic mice produce significantly lower levels of IFNG than those from NOD controls

increased interleukin-4 secretion ( J:36435 )

• IL-4 levels produced by GAD65 responsive T cells of transgenic mice are 9-fold higher compared to NOD controls

autoimmune response ( J:36435 )

• transgenic mice develop autoimmune pathologies against salivary gland, thyroid and kidney comparable to conrol NOD mice, but no islet-directed autoimmune response is observed

decreased susceptibility to autoimmune diabetes ( J:36435 )

• no males develop diabetes (blood glucose >300 mg/dl) during the 40 week evaluation period compared to 60% incidence in non-transgenic NOD male controls; 25% of females develop diabetes by 40 weeks compared to 90% of NOD control females

endocrine/exocrine glands

insulitis ( J:36435 )

• at 40 weeks, pancreata of females show widespread invasive and destructive insulits, while males exhibit mild insulitis

• transgenic mice developed diabetes at a higher incidence when injected with cyclophosphamide at 11 weeks compared to 6 weeks of age, indicating that insulitis is increasing in severity with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:36435