Phenotypes associated with this allele

• Allele Symbol: Tg(CETP)UCTP20Pnu
• Allele Name: transgene insertion UCTP20, Pharmacia & Upjohn
• Allele ID: MGI:3052658
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CETP)UCTP20Pnu/0	C57BL/6-Tg(CETP)UCTP20Pnu	MGI:3798963

Genotype
MGI:3798963

tg1

• Allelic Composition: Tg(CETP)UCTP20Pnu/0
• Genetic Background: C57BL/6-Tg(CETP)UCTP20Pnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:92448 , J:118358 )

• chow-fed mice have cholesterol levels about half that of male wild-type mice (J:92448)

• male mice fed a high fat, high cholesterol (HFHC) diet have a mean cholesterol level of 250 mg/dl compared to 163 mg/dl for male wild-type mice fed the same diet (J:92448)

• female mice fed a HFHC diet for 7 weeks have a mean cholesterol level of 191 mg/dl compared to 153 mg/dl for female wild-type mice fed the same diet (J:92448)

• chow fed mice have lower mean total cholesterol than control mice (61 mg/dl vs. 96 mg/dl (J:118358)

• the ratio of (VLDL + LDL) to HDL is three times higher than in wild-type mice (J:118358)

• mean total cholesterol levels are similar to the high levels in wild-type mice when both groups are fed a HFHC diet (J:118358)

• the ratio of (VLDL + LDL) to HDL remains two-three times higher on the HFHC diet (J:118358)

decreased circulating HDL cholesterol level ( J:118358 )

• HDL levels are half that found in wild-type mice when both groups are fed a chow diet

• HDL levels continue to be lower than wild-type mice when both groups are fed a HFHC diet

increased circulating LDL cholesterol level ( J:118358 )

• VLDL/LDL levels are a third higher in chow-fed mice compared to wild-type mice

• VLDL/LDL levels remain higher than in wild-type mice when both groups are fed a HFHC diet

increased circulating VLDL cholesterol level ( J:118358 )

• VLDL/LDL levels are a third higher in chow-fed mice compared to wild-type mice

• VLDL/LDL levels remain higher than in wild-type mice when both groups are fed a HFHC diet

abnormal circulating protein level ( J:92448 )

• mice have higher blood levels of Apo-A-I and Apo-B compared to sex-matched control mice

• the levels of Apo-B but not Apo-A-I increase to a greater extent than controls when mice are fed a high fat, high cholesterol (HFHC) diet for 7 weeks

• the size of the Apo-B particles are bigger in the transgenic mice fed the HFHC diet than in the wild-type control mice fed the same diet

• the size of the Apo-A-I particles are significantly smaller in the transgenic mice fed a chow diet

cardiovascular system

increased susceptibility to atherosclerosis ( J:118358 )

• mice have a mean lesion area 3 times that of control mice when both groups are fed a HFHC diet for 28 weeks

• significant increases in lesion area are evident by 18 weeks of age

• lesions after 28 weeks of the HFHC diet are large and focal compared to the more diffuse ribbon lesions observed in the control mice