Phenotypes associated with this allele

• Allele Symbol: Adam1a^tm1Tba
• Allele Name: targeted mutation 1, Tadashi Baba
• Allele ID: MGI:3052660
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam1a^tm1Tba/Adam1a^tm1Tba	involves: 129S2/SvPas * ICR	MGI:3052706

Genotype
MGI:3052706

hm1

• Allelic Composition: Adam1a^tm1Tba/Adam1a^tm1Tba
• Genetic Background: involves: 129S2/SvPas * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

impaired sperm migration in female genital tract ( J:92271 )

♂ • homozygous sperm are unable to migrate from the uterus into the oviduct through the uterotubal junction

male infertility ( J:92271 )

♂ • males are essentially sterile with only 1 litter with 2 pups produced after 24 homozygous males were mated with 61 heterozygous females

abnormal fertilization ( J:92271 )

• homozygous sperm displays a significant delay in the dispersal of cumulus cells and impaired binding to the zona pellucida during in vitro fertilization but is still able to fertilize cumulus-intact, zona-intact eggs normally

impaired binding of sperm to zona pellucida ( J:92271 )

♂ • homozygous sperm show impaired binding to the zona pellucida during in vitro fertilization

cellular

impaired sperm migration in female genital tract ( J:92271 )

♂ • homozygous sperm are unable to migrate from the uterus into the oviduct through the uterotubal junction