Phenotypes associated with this allele

• Allele Symbol: Mtor^tm1Yam
• Allele Name: targeted mutation 1, Shinya Yamanaka
• Allele ID: MGI:3052669
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtor^tm1Yam/Mtor^tm1Yam	involves: 129S4/SvJae	MGI:3052692

Genotype
MGI:3052692

hm1

• Allelic Composition: Mtor^tm1Yam/Mtor^tm1Yam
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:92252 )

• homozygous embryos die around 6.5 to 7.5 dpc

embryo

absent inner cell mass proliferation ( J:92252 )

• cultured 3.5-dpc blastocysts fail to show proliferation of the inner cell mass (ICM) compared to wild-type blastocysts

abnormal gastrulation ( J:92252 )

• embryos at 6.5 dpc develop epiblasts and visceral and parietal endoderm, but with significantly fewer cells than in wild-type embryos which undergo normal gastrulation

abnormal trophoblast layer morphology ( J:92252 )

• trophoblasts of cultured 3.5 dpc blastocysts fail to proliferate, in contrast to wild-type and heterozygous blastocysts which show normal growth and expansion in culture

cellular

absent inner cell mass proliferation ( J:92252 )

• cultured 3.5-dpc blastocysts fail to show proliferation of the inner cell mass (ICM) compared to wild-type blastocysts