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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(APOA2)3Rub
transgene insertion 3, Edward M Rubin
MGI:3052677
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoa1tm1Unc/Apoa1tm1Unc
Tg(APOA2)3Rub/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3783804
cx2
 		Tg(APOA1)1Rub/0
Tg(APOA2)3Rub/0 		involves: C57BL/6 MGI:3783805
cx3
 		Tg(APOA1)1Rub/?
Tg(APOA2)3Rub/? 		involves: C57BL/6 MGI:3800811
cx4
 		Tg(AlbLCAT)1Jdm/0
Tg(APOA2)3Rub/0 		involves: C57BL/6 * FVB/N MGI:3835378
cx5
 		Tg(AlbLCAT)1Jdm/0
Tg(APOA1)1Rub/0
Tg(APOA2)3Rub/0 		involves: C57BL/6 * FVB/N MGI:3835379
tg6
 		Tg(APOA2)3Rub/0 involves: C57BL/6 MGI:3835377
tg7
 		Tg(APOA2)3Rub/? involves: C57BL/6 MGI:3800810


Genotype
MGI:3783804
cx1
Allelic
Composition		 Apoa1tm1Unc/Apoa1tm1Unc
Tg(APOA2)3Rub/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1tm1Unc mutation (2 available); any Apoa1 mutation (15 available)
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:129136 )
• while serum cholesterol is decreased there is an increase in the ratio of unesterified to esterified cholesterol compared to in Apoa1tm1Unc homozygotes
increased circulating triglyceride level ( J:129136 )
• triglyceride levels are increased compared to in Apoa1tm1Unc homozygotes




Genotype
MGI:3783805
cx2
Allelic
Composition		 Tg(APOA1)1Rub/0
Tg(APOA2)3Rub/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APOA1)1Rub mutation (1 available)
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cholesterol efflux ( J:129136 )
• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub

homeostasis/metabolism
increased cholesterol efflux ( J:129136 )
• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
increased circulating cholesterol level ( J:129136 )
• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
increased circulating HDL cholesterol level ( J:129136 )
• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
increased circulating triglyceride level ( J:129136 )
• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub




Genotype
MGI:3800811
cx3
Allelic
Composition		 Tg(APOA1)1Rub/?
Tg(APOA2)3Rub/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APOA1)1Rub mutation (1 available)
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:92450 , J:129704 )
• HDL particle size has a broad size distribution between 8 and 9.5 nm but is missing the 10.5 nm particles observed in mice carrying just the Tg(APOA1)1Rub transgene (J:92450)
• HDL particle size has a broad size distribution similar to human HDL particles that contain apoA-I and apoA-II (J:129704)

cardiovascular system
decreased susceptibility to atherosclerosis ( J:129704 )
• there is a 2.7-fold reduction in the mean lesion area found in the aorta of mice fed an atherogenic diet for 36 weeks compared to wild-type mice




Genotype
MGI:3835378
cx4
Allelic
Composition		 Tg(AlbLCAT)1Jdm/0
Tg(APOA2)3Rub/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(AlbLCAT)1Jdm mutation (1 available)
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:3835379
cx5
Allelic
Composition		 Tg(AlbLCAT)1Jdm/0
Tg(APOA1)1Rub/0
Tg(APOA2)3Rub/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(AlbLCAT)1Jdm mutation (1 available)
Tg(APOA1)1Rub mutation (1 available)
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:121992 )
• 2-fold compared to in Tg(APOA1)1Rub Tg(APOA2)3Rub mice
increased circulating HDL cholesterol level ( J:121992 )
• 2-fold compared to in Tg(AlbLCAT)1Jdm or Tg(APOA1)1Rub Tg(APOA2)3Rub mice




Genotype
MGI:3835377
tg6
Allelic
Composition		 Tg(APOA2)3Rub/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:3800810
tg7
Allelic
Composition		 Tg(APOA2)3Rub/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APOA2)3Rub mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:92450 )
• a mean concentration of 34 mg/dl of human ApoA-II homodimer is found in the sera of mice without affecting the expression of endogenous apoliproteins
• HDL particle size has a bimodal distribution with two peaks at 8.0 and 9.6 nm compared to the single peak at 9.9 nm for non-transgenic controls
• the small size HDL particle contains the human ApoA-II




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory