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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chst2tm1Tmu
targeted mutation 1, Takashi Muramatsu
MGI:3052713
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chst2tm1Tmu/Chst2tm1Tmu involves: 129S2/SvPas * C57BL/6J MGI:3053811
cx2
 		Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr 		involves: 129S2/SvPas MGI:5543509
cx3
 		Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr 		involves: 129S2/SvPas * C57BL/6NTac MGI:5543506


Genotype
MGI:3053811
hm1
Allelic
Composition		 Chst2tm1Tmu/Chst2tm1Tmu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:92231 )
• decreased lymphocyte binding to peripheral lymph node high endothelial venules
abnormal leukocyte migration ( J:92231 )
• diminished lymphocyte homing in peyer's patches, peripheral and mesenteric lymph nodes

cellular
abnormal leukocyte migration ( J:92231 )
• diminished lymphocyte homing in peyer's patches, peripheral and mesenteric lymph nodes

hematopoietic system
abnormal leukocyte physiology ( J:92231 )
• decreased lymphocyte binding to peripheral lymph node high endothelial venules
abnormal leukocyte migration ( J:92231 )
• diminished lymphocyte homing in peyer's patches, peripheral and mesenteric lymph nodes




Genotype
MGI:5543509
cx2
Allelic
Composition		 Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
Chst4tm1Sdr mutation (1 available); any Chst4 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal leukocyte migration ( J:204813 )
• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

hematopoietic system
abnormal leukocyte migration ( J:204813 )
• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

immune system
abnormal leukocyte migration ( J:204813 )
• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice




Genotype
MGI:5543506
cx3
Allelic
Composition		 Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NTac
Cell Lines 10172A-D6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1tm1(KOMP)Vlcg mutation (2 available); any Chst1 mutation (20 available)
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
Chst4tm1Sdr mutation (1 available); any Chst4 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal

cellular
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal

hematopoietic system
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory