Phenotypes associated with this allele

• Allele Symbol: Epor^{tm1.1(EGFP/icre)Uk}
• Allele Name: targeted mutation 1.1, Ursula Klingmuller
• Allele ID: MGI:3052727
• Summary: 11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epor^tm1.1(EGFP/icre)Uk/Epor^tm1.1(EGFP/icre)Uk	involves: BALB/cJ	MGI:3718192
cn2	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a^+ Epor^tm1.1(EGFP/icre)Uk/Epor^+	involves: 129 * BALB/cJ	MGI:5515311
cn3	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Epor^tm1.1(EGFP/icre)Uk/Epor^+	involves: 129 * BALB/cJ	MGI:5515313
cn4	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Epor^tm1.1(EGFP/icre)Uk/Epor^+ Tg(HBB)8.1Gvs/0	involves: 129 * BALB/cJ * FVB/N	MGI:5496871
cn5	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Klf1^tm1Nimr/Klf1^+ Epor^tm1.1(EGFP/icre)Uk/Epor^+ Tg(HBB)8.1Gvs/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:5496872
cn6	Eed^tm1Sho/Eed^tm1Sho Epor^tm1.1(EGFP/icre)Uk/Epor^+ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:4410547
cn7	Epor^tm1.1(EGFP/icre)Uk/Epor^+ Rasa3^tm1.1Llp/Rasa3^tm1.1Llp	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J	MGI:6509624
cn8	Epor^tm1.1(EGFP/icre)Uk/Epor^+ Rasa3^tm1.1Llp/Rasa3^tm1.3Llp	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J	MGI:6510263
cn9	Slc29a1^tm2Msg/Slc29a1^tm2Msg Epor^tm1.1(EGFP/icre)Uk/Epor^+	involves: 129X1/SvJ * BALB/cJ	MGI:6151074
cn10	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Epor^tm1.1(EGFP/icre)Uk/Epor^+	involves: BALB/cJ	MGI:5515310
cn11	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Epor^tm1.1(EGFP/icre)Uk/Epor^+	involves: BALB/cJ * C57BL/6	MGI:6712738

Genotype
MGI:3718192

hm1

• Allelic Composition: Epor^{tm1.1(EGFP/icre)Uk}/Epor^{tm1.1(EGFP/icre)Uk}
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92235 )

• mice die at E12.5

Genotype
MGI:5515311

cn2

• Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt; Kdm1a^tm1.1Sho/Kdm1a⁺; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
• Genetic Background: involves: 129 * BALB/cJ

hematopoietic system

anemia ( J:196140 )

• mild

decreased erythrocyte cell number ( J:196140 )

decreased hemoglobin content ( J:196140 )

Genotype
MGI:5515313

cn3

• Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
• Genetic Background: involves: 129 * BALB/cJ

embryo

decreased embryo size ( J:201572 )

• embryos are smaller than control at E13.5

growth/size/body

decreased embryo size ( J:201572 )

• embryos are smaller than control at E13.5

hematopoietic system

abnormal erythropoiesis ( J:201572 )

abnormal proerythroblast morphology ( J:201572 )

• 300% increase in CD71^hi Ter119^low proerythroblasts found in fetal liver cells

decreased fetal derived definitive erythrocyte cell number ( J:201572 )

• 20-fold decrease in number of erythrocytes found in fetal (E13.5) liver cells

reticulocytopenia ( J:201572 )

• 20-fold decrease in number of reticulocytes found in fetal (E13.5) liver cells

liver/biliary system

abnormal liver morphology ( J:201572 )

• E13.5 livers exhibit a disturbed architecture with multiple pyknotic cells displaying karyorrhexis

pale liver ( J:201572 )

• fetal liver (E13.5) is pale

Genotype
MGI:5496871

cn4

• Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Tg(HBB)8.1Gvs/0
• Genetic Background: involves: 129 * BALB/cJ * FVB/N

mortality/aging

mortality/aging ( J:196405 )

N • mice are produced in expected Mendelian ratios

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased Ter119+/CD71+ cells in the blood

• increased Ter119+/DRAQ5+ cells in the blood

anemia ( J:196405 )

• mild

decreased erythrocyte cell number ( J:196405 )

• small

decreased hematocrit ( J:196405 )

• small

decreased hemoglobin content ( J:196405 )

• small

reticulocytosis ( J:196405 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:196405 )

• indicating anemic stress

Genotype
MGI:5496872

cn5

• Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu; Klf1^tm1Nimr/Klf1⁺; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Tg(HBB)8.1Gvs/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased Ter119+/CD71+ cells in the blood

polychromatophilia ( J:196405 )

Genotype
MGI:4410547

cn6

• Allelic Composition: Eed^tm1Sho/Eed^tm1Sho; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

hematopoietic system

abnormal erythropoiesis ( J:154730 )

• increase in the percentage of cells in the R2 stage (lin-,CD71+,Ter119-) and reduction in the percentage of cells in the R3 stage (lin-,CD71+,Ter119+)

Genotype
MGI:6509624

cn7

• Allelic Composition: Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Rasa3^tm1.1Llp/Rasa3^tm1.1Llp
• Genetic Background: involves: 129S1/SvImJ * BALB/cJ * C57BL/6J

hematopoietic system

hematopoietic system phenotype ( J:301035 )

N • although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes

Genotype
MGI:6510263

cn8

• Allelic Composition: Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺; Rasa3^tm1.1Llp/Rasa3^tm1.3Llp
• Genetic Background: involves: 129S1/SvImJ * BALB/cJ * C57BL/6J

hematopoietic system

hematopoietic system phenotype ( J:301035 )

N • although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes

Genotype
MGI:6151074

cn9

• Allelic Composition: Slc29a1^tm2Msg/Slc29a1^tm2Msg; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
• Genetic Background: involves: 129X1/SvJ * BALB/cJ

homeostasis/metabolism

abnormal response to injury ( J:244602 )

• under acute hypoxic conditions, mice exhibit a faster increase in serum adenosine levels than in wild-type mice

decreased susceptibility to injury ( J:244602 )

• under acute hypoxic conditions, mice exhibit reduced tissue hypoxia in the heart, kidney and lung with reduced total cell numbers, albumin and IL6 concentration bronchoalveolar lavage fluid, pulmonary myeloperoxidase activity, and perivascular edema compared with wild-type mice

immune system

decreased interleukin-6 secretion ( J:244602 )

• in the lungs of mice exposed to hypoxic conditions

Genotype
MGI:5515310

cn10

• Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
• Genetic Background: involves: BALB/cJ

hematopoietic system

hematopoietic system phenotype ( J:196140 )

N • mice exhibit normal red blood cell numbers, white blood cell numbers and hemoglobin content

Genotype
MGI:6712738

cn11

• Allelic Composition: Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
• Genetic Background: involves: BALB/cJ * C57BL/6

hematopoietic system

increased erythroid progenitor cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in RIII and RIV erythroid precursors in the bone marrow compared to controls

increased erythrocyte cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in peripheral blood red blood cell numbers compared to controls

increased hematocrit ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in hematocrit compared to controls

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:305794 )

• mice show alleviation of stress-induced anemia, showing increased peripheral blood cell counts, increased hematocrit, and increase in erythroid precursors in the bone marrow following phenylhydrazine-induced stress erythropoiesis