Phenotypes associated with this allele

• Allele Symbol: Parg^tm1Zqw
• Allele Name: targeted mutation 1, Zhao-Qi Wang
• Allele ID: MGI:3052740
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Parg^tm1Zqw/Parg^tm1Zqw	involves: 129P2/OlaHsd * C57BL/6	MGI:3053835

Genotype
MGI:3053835

hm1

• Allelic Composition: Parg^tm1Zqw/Parg^tm1Zqw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:92244 )

• start dying about 3 weeks after irradiation as opposed to 12 weeks for controls

increased susceptibility to xenobiotic induced morbidity/mortality ( J:92244 )

• increased sensitivity to N-methyl-N-nitrosourea, start to die 8 weeks after treatment as opposed to 13 weeks in controls

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:92244 )

• beta cell loss due to streptozotocin is greater than in wild-type controls

homeostasis/metabolism

increased circulating glucose level ( J:92244 )

• significantly elevated blood glucose 2-9 days after streptozotocin treatment

increased circulating tumor necrosis factor level ( J:92244 )

• serum TNF-alpha levels increased after LPS treatment

increased mortality induced by gamma-irradiation ( J:92244 )

• start dying about 3 weeks after irradiation as opposed to 12 weeks for controls

increased susceptibility to xenobiotic induced morbidity/mortality ( J:92244 )

• increased sensitivity to N-methyl-N-nitrosourea, start to die 8 weeks after treatment as opposed to 13 weeks in controls

immune system

increased circulating tumor necrosis factor level ( J:92244 )

• serum TNF-alpha levels increased after LPS treatment

increased susceptibility to endotoxin shock ( J:92244 )

• become hypersensitive to septic shock induced by LPS, dying within 2 days of treatment