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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gys1Gt(OST33395)Lex
gene trap OST33395, Lexicon Genetics
MGI:3052742
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gys1Gt(OST33395)Lex/Gys1Gt(OST33395)Lex involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6J MGI:3053443


Genotype
MGI:3053443
hm1
Allelic
Composition
Gys1Gt(OST33395)Lex/Gys1Gt(OST33395)Lex
Genetic
Background
involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys1Gt(OST33395)Lex mutation (1 available); any Gys1 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most pups die at birth without inflating their lungs
• about 10% of homozygotes survive to maturity

cardiovascular system
• at E14.5 embryos have a congested venous system
• at E14.5 and E18.5 both atria are dilated
• surviving homozygous male mutants have significantly increased heart weights
• at E14.5 and E18.5 the ventricles are smaller
• at E14.5 and E18.5 reduced trabecular structure is seen
• at E14.5 ventricular septal abnormalities are seen
• at E14.5 and E18.5 the ventricles have thinner walls compared to wild-type mice
• in some cases an increased pericardial space is seen
• 12 and 16 month old surviving homozygous male mutants display cardiac fibrosis
• pooling of blood is seen in mutant atria
• liver hemorrhages are seen at E14.5
• reduced cardiomyocyte proliferation is seen in the wall of mutant heart ventricles

homeostasis/metabolism
• surviving homozygous mutants are glycogen deficient

muscle
• at E14.5 and E18.5 reduced trabecular structure is seen
• reduced cardiomyocyte proliferation is seen in the wall of mutant heart ventricles

respiratory system

cellular
• reduced cardiomyocyte proliferation is seen in the wall of mutant heart ventricles

liver/biliary system
• liver hemorrhages are seen at E14.5

growth/size/body
• surviving homozygous male mutants have significantly increased heart weights





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory