mortality/aging
• median survival time is around 6 months with about 60% of the deaths due to circulatory failure
(J:92264)
• survival time for homozygotes born from heterozygous mothers is shorter than that of homozygotes born from homozygous mothers
(J:92264)
• median survival is 7 weeks
(J:202757)
|
cardiovascular system
• degeneration of myocytes with edema between the myofibers is seen
|
• mutants that died due to circulatory failure displayed mild to severe cardiomyopathy with 1/3 having a heart 2 to 3 times larger than normal
• cardiomyopathy is not due to increased susceptibility to cardiotoxic viruses
• along with thrombosis one or both atria are enlarged
|
• inflammatory changes in the heart
|
myocarditis
(
J:92264
)
• inflammation of the endothelium extending into the muscle wall is seen in mutant atria
|
hematopoietic system
• atrophy of the cortical area of the thymus is seen
|
• in less than 10% of older mice enlarged spleens are seen
|
• enlarged B-cell follicles are seen
|
• indistinct marginal zones are seen
|
immune system
• inflammatory changes in the heart
|
myocarditis
(
J:92264
)
• inflammation of the endothelium extending into the muscle wall is seen in mutant atria
|
• atrophy of the cortical area of the thymus is seen
|
• in less than 10% of older mice enlarged spleens are seen
|
• enlarged B-cell follicles are seen
|
• indistinct marginal zones are seen
|
• in less than 10% of older mice enlarged lymph nodes are seen
|
• production of type I interferon is reduced in MEFs following transfection with dsDNA (calf thymus DNA)
|
• inflammatory changes in the skin
|
liver/biliary system
• necrotic areas in the liver are occasionally seen
|
muscle
• degeneration of myocytes with edema between the myofibers is seen
|
• mutants that died due to circulatory failure displayed mild to severe cardiomyopathy with 1/3 having a heart 2 to 3 times larger than normal
• cardiomyopathy is not due to increased susceptibility to cardiotoxic viruses
• along with thrombosis one or both atria are enlarged
|
renal/urinary system
• necrotic areas in the kidney are occasionally seen
|
homeostasis/metabolism
• thrombus formation is seen in one or both of the atria in mutants that died from circulatory failure
|
integument
• inflammatory changes in the skin
|
endocrine/exocrine glands
• atrophy of the cortical area of the thymus is seen
|
growth/size/body
• in less than 10% of older mice enlarged spleens are seen
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Aicardi-Goutieres syndrome | DOID:0050629 |
OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750 |
J:145466 |