About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mt1)174Bri
transgene insertion 174, Ralph L Brinster
MGI:3052794
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Atp7aMo-brJ/Atp7a+
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
Tg(Mt1)174Bri/0 		involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL MGI:4361575
tg2
 		Tg(Mt1)174Bri/Tg(Mt1)174Bri involves: C57BL/6 * SJL MGI:3798856
tg3
 		Tg(Mt1)174Bri/0 B6.Cg-Tg(Mt1)174Bri/J MGI:4361627
tg4
 		Tg(Mt1)174Bri/0 involves: C57BL/6 * SJL MGI:3798838


Genotype
MGI:4361575
cx1
Allelic
Composition		 Atp7aMo-brJ/Atp7a+
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
Tg(Mt1)174Bri/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-brJ mutation (0 available); any Atp7a mutation (69 available)
Mt1tm1Bri mutation (1 available); any Mt1 mutation (49 available)
Mt2tm1Bri mutation (1 available); any Mt2 mutation (9 available)
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:33276 )
• mice are phenotypically normal




Genotype
MGI:3798856
tg2
Allelic
Composition		 Tg(Mt1)174Bri/Tg(Mt1)174Bri
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal mineral absorption ( J:47419 )
• 2 hours after oral dosing with zinc, mice have about a 2-fold less zinc concentration in the blood than in control mice

homeostasis/metabolism
abnormal response to cardiac infarction ( J:85798 )
• the mean percentage of apoptotic cells present in the myocardium after ischemia/reperfusion is 14.4% compared to 26.3%
• myocardial oxidative damage is reduced by almost two-thirds as measured by levels of lipid peroxidation found in the heart after ischemia/reperfusion
decreased myocardial infarct size ( J:85798 )
• only small scattered infarct zones are present after ischemia/reperfusion-induced myocardial infarction
• area of tissue with infarctions visible is only about half that of non-transgenic controls

cardiovascular system
abnormal response to cardiac infarction ( J:85798 )
• the mean percentage of apoptotic cells present in the myocardium after ischemia/reperfusion is 14.4% compared to 26.3%
• myocardial oxidative damage is reduced by almost two-thirds as measured by levels of lipid peroxidation found in the heart after ischemia/reperfusion
decreased myocardial infarct size ( J:85798 )
• only small scattered infarct zones are present after ischemia/reperfusion-induced myocardial infarction
• area of tissue with infarctions visible is only about half that of non-transgenic controls




Genotype
MGI:4361627
tg3
Allelic
Composition		 Tg(Mt1)174Bri/0
Genetic
Background		 B6.Cg-Tg(Mt1)174Bri/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:120196 )
• treated-treated mice exhibit increased mean survival time compared with similarly treated wild-type mice

homeostasis/metabolism
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:120196 )
• treated-treated mice exhibit increased mean survival time compared with similarly treated wild-type mice




Genotype
MGI:3798838
tg4
Allelic
Composition		 Tg(Mt1)174Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal mineral level ( J:29102 )
• mice have 50% more zinc in the liver and 3-fold more zinc in the pancreas than is found in non-transgenic littermate controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory