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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prnptm1Tuzi
targeted mutation 1, Nadia L Tuzi
MGI:3052798
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Prnptm1Tuzi/Prnp+ involves: 129P2/OlaHsd MGI:3053018
ht2
 		Prnptm1Tuzi/Prnptm2Edin involves: 129P2/OlaHsd MGI:3053020
cn3
 		Prnptm1Tuzi/Prnp+
Tg(CMV-cre)1Cgn/? 		involves: 129P2/OlaHsd * BALB/cJ MGI:3053021
cn4
 		Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/? 		involves: 129P2/OlaHsd * BALB/cJ MGI:3053022


Genotype
MGI:3053018
ht1
Allelic
Composition		 Prnptm1Tuzi/Prnp+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• an increased incubation time for TSE strain ME7 compared to wild-type mice is seen, however this incubation time is longer than in heterozygous Prnptm2Edin mice




Genotype
MGI:3053020
ht2
Allelic
Composition		 Prnptm1Tuzi/Prnptm2Edin
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (142 available)
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• no signs of TSE disease are seen 410 days postinfection an increased incubation time compared to wild-type mice or mutants with cre recombination




Genotype
MGI:3053021
cn3
Allelic
Composition		 Prnptm1Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (142 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:92302 )
N
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that in wild-type mice




Genotype
MGI:3053022
cn4
Allelic
Composition		 Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (142 available)
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory