Phenotypes associated with this allele

• Allele Symbol: Ubp1^tm1Jmc
• Allele Name: targeted mutation 1, John M Cunningham
• Allele ID: MGI:3052819
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ubp1^tm1Jmc/Ubp1^tm1Jmc	involves: 129S7/SvEvBrd * C57BL/6	MGI:3052830

Genotype
MGI:3052830

hm1

• Allelic Composition: Ubp1^tm1Jmc/Ubp1^tm1Jmc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92266 )

• no homozygotes born

• all homozygous embryos dead at E11.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:92266 )

• lack of intricate branching network of embryonic vessels

• close apposition of fetal vessels with maternal blood vessels not seen

abnormal angiogenesis ( J:92266 )

• although vasculogenesis is initiated normally, angiogenesis fails

absent vitelline blood vessels ( J:92266 )

• absence of large vitelline blood vessels

disorganized yolk sac vascular plexus ( J:92266 )

• absence of extensive vascular network

• disorganized vascular pattern

• vessels with thinner walls and sparse endothelial cell lining

abnormal heart morphology ( J:92266 )

trabecula carnea hypoplasia ( J:92266 )

• occasionally reduced trabeculations

thin myocardium ( J:92266 )

• occasionally thinned myocardial layer

distended pericardium ( J:92266 )

• dilated pericardial sac at E10.5

dilated heart ( J:92266 )

• dilated cardiac chambers occasionally

hemorrhage ( J:92266 )

• pools of fetal blood in amniotic cavity

embryo

absent vitelline blood vessels ( J:92266 )

• absence of large vitelline blood vessels

embryonic growth retardation ( J:92266 )

• at E10.5, embryo development delayed about 0.5 days

decreased embryo size ( J:92266 )

• embryos at E10.5 significantly smaller

abnormal placenta labyrinth morphology ( J:92266 )

• placentation and initiation of vascular penetration was normal but there was a decreased thickness of the labyrinth layer

abnormal placental labyrinth vasculature morphology ( J:92266 )

• lack of intricate branching network of embryonic vessels

• close apposition of fetal vessels with maternal blood vessels not seen

abnormal visceral yolk sac morphology ( J:92266 )

disorganized yolk sac vascular plexus ( J:92266 )

• absence of extensive vascular network

• disorganized vascular pattern

• vessels with thinner walls and sparse endothelial cell lining

growth/size/body

embryonic growth retardation ( J:92266 )

• at E10.5, embryo development delayed about 0.5 days

decreased embryo size ( J:92266 )

• embryos at E10.5 significantly smaller

muscle

trabecula carnea hypoplasia ( J:92266 )

• occasionally reduced trabeculations

thin myocardium ( J:92266 )

• occasionally thinned myocardial layer