Phenotypes associated with this allele

• Allele Symbol: Myocd^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:3052940
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myocd^tm1Eno/Myocd^tm1Eno	involves: 129S/SvEv * C57BL/6	MGI:3052977

Genotype
MGI:3052977

hm1

• Allelic Composition: Myocd^tm1Eno/Myocd^tm1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84789 )

• homozygous mutants were detected up to E10.5, but not thereafter

cardiovascular system

cardiovascular system phenotype ( J:84789 )

N • normal heart gross morphology with normal looping and chamber formation

abnormal blood vessel morphology ( J:84789 )

• severe vascular defects were observed, including underdeveloped dorsal aortae although the anterior cardinal veins appeared normal

abnormal dorsal aorta morphology ( J:84789 )

• dorsal aortae are underdeveloped

absent vitelline blood vessels ( J:84789 )

abnormal vascular smooth muscle morphology ( J:84789 )

• absence of smooth muscle cells at E9.5 in dorsal aortae was determined by alpha-actin immunohistochemistry

pericardial effusion ( J:84789 )

• pericardial effusion observed at E10.5

embryo

absent vitelline blood vessels ( J:84789 )

embryonic growth retardation ( J:84789 )

• delayed embryonic growth observed at E9.5

pale yolk sac ( J:84789 )

muscle

abnormal vascular smooth muscle morphology ( J:84789 )

• absence of smooth muscle cells at E9.5 in dorsal aortae was determined by alpha-actin immunohistochemistry

growth/size/body

embryonic growth retardation ( J:84789 )

• delayed embryonic growth observed at E9.5

homeostasis/metabolism

pericardial effusion ( J:84789 )

• pericardial effusion observed at E10.5