About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(BCL2)25Wehi
transgene insertion 25, Walter and Eliza Hall Institute of Medical Research
MGI:3052945
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0 		involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5805810
cx2
 		Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0 		involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5441334
tg3
 		Tg(BCL2)25Wehi/0 involves: C57BL/6JWehi * SJL/JWehi MGI:3697916


Genotype
MGI:5805810
cn1
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(BCL2)25Wehi mutation (1 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes

endocrine/exocrine glands
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes

hematopoietic system
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes




Genotype
MGI:5441334
cx2
Allelic
Composition		 Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)25Wehi mutation (1 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:131912 )
• median survival is 337 days

neoplasm
increased plasmacytoma incidence ( J:131912 )
• aggressive extramedullary monoclonal plasmacytoma with infiltration of spleen and lymph nodes




Genotype
MGI:3697916
tg3
Allelic
Composition		 Tg(BCL2)25Wehi/0
Genetic
Background		 involves: C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)25Wehi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
abnormal plasma cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
increased T cell number ( J:93111 )
• mutants have a 2-fold excess of T lymphocytes in peripheral lymphoid organs
abnormal T cell physiology ( J:93111 )
• transgenic T cells from thymus or periphery show prolonged in vitro survival in culture compared to wild-type T lymphocytes

immune system
abnormal B cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
abnormal plasma cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
increased T cell number ( J:93111 )
• mutants have a 2-fold excess of T lymphocytes in peripheral lymphoid organs
abnormal T cell physiology ( J:93111 )
• transgenic T cells from thymus or periphery show prolonged in vitro survival in culture compared to wild-type T lymphocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory