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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(BCL2)36Wehi
transgene insertion 36, Walter and Eliza Hall Institute of Medical Research
MGI:3052954
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834731
cx2
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0 		involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi MGI:3796509
tg3
 		Tg(BCL2)36Wehi/0 involves: C57BL/6JWehi * SJL/JWehi MGI:3697911
tg4
 		Tg(BCL2)36Wehi/? B6.Cg-Tg(BCL2)36Wehi/J MGI:3851985


Genotype
MGI:3834731
cn1
Allelic
Composition		 Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(BCL2)36Wehi mutation (2 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:63282 )
• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

immune system
immune system phenotype ( J:63282 )
N
• thymus cellularity restored




Genotype
MGI:3796509
cx2
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased follicular B cell number ( J:130950 )
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene

hematopoietic system
decreased follicular B cell number ( J:130950 )
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene




Genotype
MGI:3697911
tg3
Allelic
Composition		 Tg(BCL2)36Wehi/0
Genetic
Background		 involves: C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors
increased B cell number ( J:93111 )
• mutants show an excess of B lymphocytes
increased T cell number ( J:93111 )
• mutants have an excess of T lymphocytes
abnormal B cell physiology ( J:93111 )
• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
increased immunoglobulin level ( J:93111 )
• mice display increased serum immunoglobulin concentrations
abnormal T cell physiology ( J:93111 )
• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes

immune system
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors
increased B cell number ( J:93111 )
• mutants show an excess of B lymphocytes
increased T cell number ( J:93111 )
• mutants have an excess of T lymphocytes
abnormal B cell physiology ( J:93111 )
• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
increased immunoglobulin level ( J:93111 )
• mice display increased serum immunoglobulin concentrations
abnormal T cell physiology ( J:93111 )
• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
increased susceptibility to autoimmune disorder ( J:93111 )
• some transgenic mice develop a systemic autoimmune-like disease

neoplasm
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors




Genotype
MGI:3851985
tg4
Allelic
Composition		 Tg(BCL2)36Wehi/?
Genetic
Background		 B6.Cg-Tg(BCL2)36Wehi/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell apoptosis ( J:90963 )
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
abnormal B cell proliferation ( J:90963 )
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

immune system
decreased B cell apoptosis ( J:90963 )
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
abnormal B cell proliferation ( J:90963 )
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

cellular
decreased B cell apoptosis ( J:90963 )
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
abnormal B cell proliferation ( J:90963 )
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory