About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(BCL2)36Wehi
transgene insertion 36, Walter and Eliza Hall Institute of Medical Research
MGI:3052954
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834731
cx2
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0 		involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi MGI:3796509
tg3
 		Tg(BCL2)36Wehi/0 involves: C57BL/6JWehi * SJL/JWehi MGI:3697911
tg4
 		Tg(BCL2)36Wehi/? B6.Cg-Tg(BCL2)36Wehi/J MGI:3851985


Genotype
MGI:3834731
cn1
Allelic
Composition		 Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(BCL2)36Wehi mutation (2 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:63282 )
• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

immune system
immune system phenotype ( J:63282 )
N
• thymus cellularity restored




Genotype
MGI:3796509
cx2
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased follicular B cell number ( J:130950 )
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene

hematopoietic system
decreased follicular B cell number ( J:130950 )
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene




Genotype
MGI:3697911
tg3
Allelic
Composition		 Tg(BCL2)36Wehi/0
Genetic
Background		 involves: C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors
increased B cell number ( J:93111 )
• mutants show an excess of B lymphocytes
increased T cell number ( J:93111 )
• mutants have an excess of T lymphocytes
abnormal B cell physiology ( J:93111 )
• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
increased immunoglobulin level ( J:93111 )
• mice display increased serum immunoglobulin concentrations
abnormal T cell physiology ( J:93111 )
• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes

immune system
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors
increased B cell number ( J:93111 )
• mutants show an excess of B lymphocytes
increased T cell number ( J:93111 )
• mutants have an excess of T lymphocytes
abnormal B cell physiology ( J:93111 )
• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
increased immunoglobulin level ( J:93111 )
• mice display increased serum immunoglobulin concentrations
abnormal T cell physiology ( J:93111 )
• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
increased susceptibility to autoimmune disorder ( J:93111 )
• some transgenic mice develop a systemic autoimmune-like disease

neoplasm
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:93111 )
• a few mice develop fatal clonal T cell tumors




Genotype
MGI:3851985
tg4
Allelic
Composition		 Tg(BCL2)36Wehi/?
Genetic
Background		 B6.Cg-Tg(BCL2)36Wehi/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell apoptosis ( J:90963 )
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
abnormal B cell proliferation ( J:90963 )
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

immune system
decreased B cell apoptosis ( J:90963 )
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
abnormal B cell proliferation ( J:90963 )
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

cellular
decreased B cell apoptosis ( J:90963 )
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
abnormal B cell proliferation ( J:90963 )
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory