normal phenotype
• homozygotes are viable and healthy with no overt phenotype detected by 20 months of age
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Allele Symbol Allele Name Allele ID |
Ptger4tm1.1Matb targeted mutation 1.1, Matthew D Breyer MGI:3052967 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes are viable and healthy with no overt phenotype detected by 20 months of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• myofiber disarray
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• length of myocytes from 31-33 week old males is increased, whereas width is normal
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• heart weight to body weight ratio is increased in aged males
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• males develop eccentric hypertrophy
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• males show reduced posterior wall thickness at diastole
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• dilated left ventricle in males and a slight increase in left ventricular dimension in females
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• 39% increase in interstitial collagen fraction and greater collagen deposition in hearts
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• older males show reduced ejection fraction and dilated left ventricle, indicating development of dilated cardiomyopathy
• females develop dilated cardiomyopathy at an older age and to a lesser extent than males
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• ejection fraction is lower in 23-33 week old males; two groups are evident, those mice with ejection fraction greater than 70% and those with ejection fraction less than 70%
• 30-32 week old females show a modest, but significant, decline in ejection fraction
• a decline in ejection fraction begins around 16 weeks of age in males and after 24-28 weeks of age in females
• however, systolic blood pressure is normal in males and females at 28 weeks of age
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• 28 week old male mice at with ejection fraction less than 70% exhibit increased left ventricular mass, increased left ventricular dimension at systole and left ventricular dimension at diastole, and reduced posterior wall thickness at diastole
• 31 week old females exhibit increased left ventricular dimension at systole
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• patches of infiltration cells in hearts, however, the percentage of macrophages is not different from wild-type mice
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• patches of infiltration cells in hearts, however, the percentage of macrophages is not different from wild-type mice
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• myofiber disarray
|
• length of myocytes from 31-33 week old males is increased, whereas width is normal
|
• older males show reduced ejection fraction and dilated left ventricle, indicating development of dilated cardiomyopathy
• females develop dilated cardiomyopathy at an older age and to a lesser extent than males
|
• ejection fraction is lower in 23-33 week old males; two groups are evident, those mice with ejection fraction greater than 70% and those with ejection fraction less than 70%
• 30-32 week old females show a modest, but significant, decline in ejection fraction
• a decline in ejection fraction begins around 16 weeks of age in males and after 24-28 weeks of age in females
• however, systolic blood pressure is normal in males and females at 28 weeks of age
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• heart weight to body weight ratio is increased in aged males
|
• males develop eccentric hypertrophy
|
• 39% increase in interstitial collagen fraction and greater collagen deposition in hearts
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:158439 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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