All Phenotypes Dspd MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dspd
dominant spermiognenesis defect
MGI:3052992

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dspd/Dspd⁺	involves: C3H * C57BL/6	MGI:3052994

Allelic Composition	Dspd/Dspd⁺
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dspd mutation (1 available); any Dspd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:89381 )

abnormal sperm head morphology ( J:89381 )

• almost all of the spermatozoa found in the epididymis have misshapen heads

abnormal spermiogenesis ( J:89381 )

• multinucleated spermatids are seen

• spermatids prematurely detach from the seminiferous epithelium

• the number of elongated spermatids is decreased compared to wild-type

reduced female fertility ( J:89381 )

• heterozygous females have reduced litter sizes

male infertility ( J:89381 )

• no offspring are obtained despite normal mating behavior however in vitro fertilization with round spermatids produces offspring

cellular

oligozoospermia ( J:89381 )

abnormal sperm head morphology ( J:89381 )

• almost all of the spermatozoa found in the epididymis have misshapen heads

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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