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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Noboxtm1Rajk
targeted mutation 1, Aleksandar Rajkovic
MGI:3053093
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Noboxtm1Rajk/Noboxtm1Rajk involves: 129S7/SvEvBrd * C57BL/6 MGI:3053462


Genotype
MGI:3053462
hm1
Allelic
Composition
Noboxtm1Rajk/Noboxtm1Rajk
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Noboxtm1Rajk mutation (1 available); any Nobox mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• by day 7, oocytes were less than 20 microns
• more oocytes in cysts than in primary follicles
• accelerated loss of oocytes; only a few remained by day 14
• oocytes absent at 6 weeks of age
• by day 14, few oocytes visible and most were degenerating

endocrine/exocrine glands
• primordial follicles present at birth, no secondary follicles by day 7
• no secondary follicles by day 7
• arrest of most oocyte and follicle growth beyond the primordial follicle stage
• only empty follicular nests by day 14
• at 6 weeks of age
• ovarian cysts present at birth

growth/size/body
• ovarian cysts present at birth

reproductive system
• by day 7, oocytes were less than 20 microns
• more oocytes in cysts than in primary follicles
• accelerated loss of oocytes; only a few remained by day 14
• oocytes absent at 6 weeks of age
• by day 14, few oocytes visible and most were degenerating
• primordial follicles present at birth, no secondary follicles by day 7
• no secondary follicles by day 7
• arrest of most oocyte and follicle growth beyond the primordial follicle stage
• only empty follicular nests by day 14
• at 6 weeks of age
• ovarian cysts present at birth





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory