All Phenotypes Scn10a<tm2(cre)Jwo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scn10a^tm2(cre)Jwo
targeted mutation 2, John N Wood
MGI:3053096

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Scn10a^tm2(cre)Jwo/Scn10a⁺ Scn9a^tm1Jwo/Scn9a^tm1Jwo	involves: 129	MGI:3053686
cn2	Braf^tm1Cpri/Braf⁺ Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * 129P2/OlaHsd	MGI:5565458
cn3	Braf^tm1Cpri/Braf⁺ Grpr^tm1Jfb/? Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * 129P2/OlaHsd * 129X1/SvJ	MGI:5565457
cn4	Braf^tm1Cpri/Braf⁺ Grp^tm1Jfb/Grp^tm1Jfb Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	MGI:5565456
cn5	Scn10a^tm2(cre)Jwo/Scn10a⁺ Slc12a6^tm2.1Dlp/Slc12a6^tm2.1Dlp	involves: 129 * 129S6/SvEvTac * C57BL/6J	MGI:5754616
cn6	Hcn2^tm1.1Lex/Hcn2^tm1.1Lex Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6	MGI:5295437
cn7	S100a10^tm1Jwo/S100a10^tm1Jwo Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6	MGI:3687277
cn8	Oprd1^tm1.1Cgrf/Oprd1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6J	MGI:5562353
cn9	Oprm1^tm1.1Cgrf/Oprm1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6J	MGI:5562337
cn10	Scn10a^tm2(cre)Jwo/Scn10a⁺ Il10ra^tm1.1Jack/Il10ra^tm1.1Jack	involves: 129P2/OlaHsd	MGI:7334745
cn11	Scn10a^tm2(cre)Jwo/Scn10a⁺ Slc17a6^tm1Kldr/Slc17a6^tm1Kldr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4887831
cn12	Scn3a^tm1.1Jwo/Scn3a^tm1.1Jwo Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5505889

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Scn9a^tm1Jwo/Scn9a^tm1Jwo
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Scn9a^tm1Jwo mutation (0 available); any Scn9a mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:92442 )

• inflammation does not result in thermal or mechanical hyperalgesia in mutants unlike in wild-type mice

abnormal pain threshold ( J:92442 )

• homozygotes are significantly less sensitive to noxious mechanical stimulation compared to wild-type mice

increased thermal nociceptive threshold ( J:92442 )

• mutants are about 20% less sensitive to noxious thermal stimulation compared to wild-type mice

Allelic Composition	Braf^tm1Cpri/Braf⁺ Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Cpri mutation (0 available); any Braf mutation (60 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:205122 )

N	• behavioral responses to pain and motor functions are similar to controls prior to the onset of scratching

enhanced behavioral response to xenobiotic ( J:205122 )

• at 4 to 6 weeks of age, show enhanced scratching responses to pruritogens injected into the nape

• both histaminergic and nonhistaminergic itch are significantly enhanced

excessive scratching ( J:205122 )

• age-dependent excessive scratching from 6 to 14 weeks of age, with about 50% of mice showing excessive scratching at 6 weeks of age

• at 4 to 6 weeks of age, show enhanced scratching responses to pruritogens injected into the nape

• both histaminergic and nonhistaminergic itch are significantly enhanced

integument

skin lesions ( J:205122 )

• develop after the onset of excessive scratching

nervous system

abnormal innervation ( J:205122 )

• increase in the density of primary afferent fibers innervating the cervical and lumbar back hairy skin regions

• in the spinal cord CGRP+ fibers expand into lamina II inner layer and nonpeptidergic

• IB4+ fibers invade into laminae I and II outer layer domains

abnormal dorsal root ganglion morphology ( J:205122 )

• increase in the number of pERK+ cells in dorsal root ganglion neurons at the cervical, thoracic and lumbar segmental levels

• the number of GRP+ neurons is nearly doubled

abnormal nervous system electrophysiology ( J:205122 )

• the percentage of single spike cells is decreased while the percentage of delayed firing cells is almost

abnormal neuron physiology ( J:205122 )

• increase in the percentage of dorsal root ganglion cells responding to chloroquine and histamine

Allelic Composition	Braf^tm1Cpri/Braf⁺ Grpr^tm1Jfb/? Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Cpri mutation (0 available); any Braf mutation (60 available)
Grpr^tm1Jfb mutation (1 available); any Grpr mutation (14 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:205122 )

N	• spontaneous scratching, seen in mutant mice wild-type for Grpr, is markedly diminished

Allelic Composition	Braf^tm1Cpri/Braf⁺ Grp^tm1Jfb/Grp^tm1Jfb Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Cpri mutation (0 available); any Braf mutation (60 available)
Grp^tm1Jfb mutation (1 available); any Grp mutation (30 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:205122 )

N	• spontaneous scratching, seen in mutant mice wild-type for Grp, is markedly diminished

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Slc12a6^tm2.1Dlp/Slc12a6^tm2.1Dlp
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Slc12a6^tm2.1Dlp mutation (0 available); any Slc12a6 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:217087 )

N	• mice display no locomotor deficit in the accelerated rotarod and open field tests and show a normal response latency to heat-evoked nociceptive stimuli in a hot plate assay

Allelic Composition	Hcn2^tm1.1Lex/Hcn2^tm1.1Lex Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2^tm1.1Lex mutation (0 available); any Hcn2 mutation (31 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal touch/ nociception ( J:176663 )

• in a neuropathic pain model, mice do not exhibit heat or mechanical hyperalgesia or cold allodynia unlike similarly treated wild-type mice

• however, mechanical hyperalgesia is normal

increased chemical nociceptive threshold ( J:176663 )

• formalin-treated mice exhibit attenuated late phase pain response compared with similarly treated wild-type mice

abnormal nociception after inflammation ( J:176663 )

• thermal hyperalgesia after carrageenan injection to induce long-lasting inflammation is completely abolished

increased thermal nociceptive threshold ( J:176663 )

• PGE2-induced thermal hyperalgesia is abolished

Allelic Composition	S100a10^tm1Jwo/S100a10^tm1Jwo Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S100a10^tm1Jwo mutation (2 available); any S100a10 mutation (34 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased single cell response intensity ( J:113256 )

• about a 50% decrease in tetrodotoxin-resistant current density in whole-cell voltage clamp assays of dorsal root ganglia neurons, but no difference in tetrodotoxin-sensitive current density

• decrease in total evoked neuron activity in wide dynamic range (WDR) spinal neurons following noxious pinch stimulation but not after noxious cold or brush stimulation

behavior/neurological

abnormal pain threshold ( J:113256 )

• increased pain threshold following noxious mechanical stimuli applied to the tail but not to the paw

• no significant difference in response to noxious radiant or in hotplate latency

allodynia ( J:113256 )

• reduction in mechanical allodynia following L5 spinal nerve injury

Allelic Composition	Oprd1^tm1.1Cgrf/Oprd1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprd1^tm1.1Cgrf mutation (1 available); any Oprd1 mutation (30 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:208176 )

N	• mice exhibit normal responses to acute noxious heat, low-threshold and noxious mechanical stimuli and chemical/early inflammatory pain in the formalin test

abnormal nociception after inflammation ( J:208176 )

• following CFA treatment, mice exhibit increased intensity and duration of mechanical allodynia compared with control mice

• however, heat hyperalgesia is normal

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:208176 )

• in a CFA-inflammatory or sciatic nerve ligation-neuropathic pain model, mice treated with systemic or intraplantar administration of the delta agonist SNC80 fail to exhibit a reduction in pain (mechanical allodynia and hyperalgesia) compared with control mice

• however, mice exhibit normal analgesic response to SNC80 during the late formalin response

Allelic Composition	Oprm1^tm1.1Cgrf/Oprm1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1.1Cgrf mutation (1 available); any Oprm1 mutation (54 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:207536 )

N	• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception

abnormal behavioral response to addictive substance ( J:207536 )

• under inflammatory pain, mice exhibit decreased mu opiate-induced analgesia compared with control mice

• under inflammatory pain, mice exhibit decreased analgesia to the peripheral opiate loperamide compared with control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207536 )

N	• morphine-induced constipation is normal

integument

integument phenotype ( J:207536 )

N	• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Il10ra^tm1.1Jack/Il10ra^tm1.1Jack
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ra^tm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:326965 )

N	• mice exhibit normal recovery from carrageenan-induced inflammatory hyperalgesia

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Slc17a6^tm1Kldr/Slc17a6^tm1Kldr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Slc17a6^tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:167752 )

N	• mice show a non-significant tendency towards increased spontaneous scratching behavior as well as a similar tendency to decreased thermal pain response • in response to an exogenous pruritogen mice show elevated scratching although response is somewhat delayed

Allelic Composition	Scn3a^tm1.1Jwo/Scn3a^tm1.1Jwo Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Scn3a^tm1.1Jwo mutation (1 available); any Scn3a mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:199857 )

N	• mice exhibit normal neuropathic pain behavior

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