All Phenotypes Scn9a<tm1Jwo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scn9a^tm1Jwo
targeted mutation 1, John N Wood
MGI:3053097

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Scn10a^tm2(cre)Jwo/Scn10a⁺ Scn9a^tm1Jwo/Scn9a^tm1Jwo	involves: 129	MGI:3053686

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Scn9a^tm1Jwo/Scn9a^tm1Jwo
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Scn9a^tm1Jwo mutation (0 available); any Scn9a mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:92442 )

• inflammation does not result in thermal or mechanical hyperalgesia in mutants unlike in wild-type mice

abnormal pain threshold ( J:92442 )

• homozygotes are significantly less sensitive to noxious mechanical stimulation compared to wild-type mice

increased thermal nociceptive threshold ( J:92442 )

• mutants are about 20% less sensitive to noxious thermal stimulation compared to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24