Phenotypes associated with this allele

• Allele Symbol: Ly96^tm1Kmiy
• Allele Name: targeted mutation 1, Kensuke Miyake
• Allele ID: MGI:3053109
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ly96^tm1Kmiy/Ly96^tm1Kmiy	involves: 129P2/OlaHsd * C57BL/6	MGI:3053346

Genotype
MGI:3053346

hm1

• Allelic Composition: Ly96^tm1Kmiy/Ly96^tm1Kmiy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune cell physiology ( J:92494 )

decreased B cell proliferation ( J:92494 )

• proliferative response to the Lipid A moiety of LPS is lacking

impaired neutrophil recruitment ( J:92479 )

• impaired recruitment of neurophils in response to gram negative infections

abnormal macrophage physiology ( J:92494 )

• macrophage production of TNFalpha and Il-6 in response to Lipid A and LTA was severely reduced

decreased interleukin-6 secretion ( J:92494 )

• production by macrophage in response to Lipid A or LTA is severely reduced

decreased tumor necrosis factor secretion ( J:92494 )

• production by macrophage in response to Lipid A or LTA is severely reduced

decreased susceptibility to endotoxin shock ( J:92494 )

• resistant to endotoxic shock when stimulated with LPS whether in conjunction with galactosamine or not

increased susceptibility to bacterial infection ( J:92494 )

• succeptibility to gram negative bacteria increased

hematopoietic system

decreased B cell proliferation ( J:92494 )

• proliferative response to the Lipid A moiety of LPS is lacking

impaired neutrophil recruitment ( J:92479 )

• impaired recruitment of neurophils in response to gram negative infections

abnormal macrophage physiology ( J:92494 )

• macrophage production of TNFalpha and Il-6 in response to Lipid A and LTA was severely reduced

cellular

decreased B cell proliferation ( J:92494 )

• proliferative response to the Lipid A moiety of LPS is lacking