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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf1atm1.1Gkl
targeted mutation 1.1, George Kollias
MGI:3053140
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl involves: 129/Sv * C57BL/6 MGI:3053727
ht2
 		Tnfrsf1atm1.1Gkl/Tnfrsf1a+ involves: 129/Sv * C57BL/6 MGI:3053732
cx3
 		Tg(TNF)197Gkl/0
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl 		involves: 129 * C57BL/6 * CBA MGI:3053722
cx4
 		Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl 		involves: 129S/SvEv * C57BL/6 MGI:3053734
cx5
 		Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl 		involves: 129/Sv * C57BL/6 MGI:3053736
cx6
 		Faslpr/Faslpr
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl 		involves: 129/Sv * C57BL/6 MGI:3053737
cx7
 		Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm 		involves: 129/Sv * C57BL/6 MGI:3053739


Genotype
MGI:3053727
hm1
Allelic
Composition		 Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:92470 )
• intravenous injection of recombinant human TNF resulted in lethality in all homozygotes compared to only 11% of wild-type mice
• increased LPS induced lethality is also seen in homozygotes compared to wild-type mice

immune system
abnormal cytokine secretion ( J:92470 )
• LPS stimulated macrophages produce more TNF and NO
increased susceptibility to experimental autoimmune encephalomyelitis ( J:92470 )
• increased susceptibility to and severity of experimental autoimmune encephalomyelitis is seen
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• iver inflammation is more severe in homozygotes compared to heterozygotes
decreased susceptibility to bacterial infection ( J:92470 )
• homozygous mice can tolerate 10-fold higher doses of Listeria monocytogenes compared to wild-type mice

liver/biliary system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• iver inflammation is more severe in homozygotes compared to heterozygotes




Genotype
MGI:3053732
ht2
Allelic
Composition		 Tnfrsf1atm1.1Gkl/Tnfrsf1a+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:92470 )
• intravenous injection of recombinant human TNF resulted in lethality in 71% of heterozygotes compared to only 11% of wild-type mice
• increased LPS induced lethality is also seen in heterozygotes compared to wild-type mice

immune system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• liver inflammation is less severe in heterozygotes compared to homozygotes

liver/biliary system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• liver inflammation is less severe in heterozygotes compared to homozygotes




Genotype
MGI:3053722
cx3
Allelic
Composition		 Tg(TNF)197Gkl/0
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNF)197Gkl mutation (2 available)
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune arthritis ( J:92470 )
• accelerated development of arthritis is seen with earlier and more severe pannus formation, articular cartilage destruction, and bone erosion

skeleton
autoimmune arthritis ( J:92470 )
• accelerated development of arthritis is seen with earlier and more severe pannus formation, articular cartilage destruction, and bone erosion




Genotype
MGI:3053734
cx4
Allelic
Composition		 Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
Tnftm1Gkl mutation (6 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:92470 )
N
• no liver inflammation is seen unlike in Tnfrsf1atm1Gkl homozygotes




Genotype
MGI:3053736
cx5
Allelic
Composition		 Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen compared to Tnfrsf1atm1Gkl in homozygotes

liver/biliary system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen compared to Tnfrsf1atm1Gkl in homozygotes




Genotype
MGI:3053737
cx6
Allelic
Composition		 Faslpr/Faslpr
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen compared to Tnfrsf1atm1Gkl in homozygotes

liver/biliary system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen compared to Tnfrsf1atm1Gkl in homozygotes




Genotype
MGI:3053739
cx7
Allelic
Composition		 Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen

liver/biliary system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory