Phenotypes associated with this allele

• Allele Symbol: Cat^b
• Allele Name: acatalasemia
• Allele ID: MGI:3053604
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cat^b/Cat^b	B6.Cg-Cat^b/Anl	MGI:4365629
hm2	Cat^b/Cat^b	C3.Cg-Cat^b/Anl	MGI:4365605
hm3	Cat^b/Cat^b	Not Specified	MGI:3615785
ht4	Cat^b/Cat^+	Not Specified	MGI:4367478

Genotype
MGI:4365629

hm1

• Allelic Composition: Cat^b/Cat^b
• Genetic Background: B6.Cg-Cat^b/Anl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:5971 )

• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:5971 )

• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole

Genotype
MGI:4365605

hm2

• Allelic Composition: Cat^b/Cat^b
• Genetic Background: C3.Cg-Cat^b/Anl

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:5971 )

• when maintained on a diet containing 1% 3-amino-1H-1,2,4-triazole, homozygotes congenic on a C3H background carrying MMTV have delayed onset of mammary tumors compared with C3H controls carrying MMTV

• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole

• fewer homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole developed tumors of the hardarian gland or ovaries subsequent to exposure to radiation

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:5971 )

• when maintained on a diet containing 1% 3-amino-1H-1,2,4-triazole, homozygotes congenic on a C3H background carrying MMTV have delayed onset of mammary tumors compared with C3H controls carrying MMTV

• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole

• fewer homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole developed tumors of the hardarian gland or ovaries subsequent to exposure to radiation

increased incidence of tumors by chemical induction ( J:5971 )

• a larger percentage of homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole develop liver tumors and these have earlier onset

neoplasm

decreased mammary gland tumor incidence ( J:5971 )

increased incidence of tumors by chemical induction ( J:5971 )

• a larger percentage of homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole develop liver tumors and these have earlier onset

increased hepatoma incidence ( J:154291 )

• mature males have increased incidence of hepatomas

liver/biliary system

increased hepatoma incidence ( J:154291 )

• mature males have increased incidence of hepatomas

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:5971 )

integument

decreased mammary gland tumor incidence ( J:5971 )

Genotype
MGI:3615785

hm3

• Allelic Composition: Cat^b/Cat^b
• Genetic Background: Not Specified

homeostasis/metabolism

decreased circulating cholesterol level ( J:5205 , J:5351 )

• average serum cholesterol is approximately 94 mg/kg instead of 111.6 mg/kg in control mice (J:5205)

decreased circulating triglyceride level ( J:5205 , J:5351 )

• serum triglyceride levels are much lower than normal (J:5205)

abnormal catalase activity ( J:5015 , J:105024 )

• blood catalase activity in homozygotes is generally below 10 perborate units per ml of whole blood (J:5015)

• very low catalase activity in blood (1.1.-2.4 PU/ml) as compared to wildtype Cat^a mice (144-155 PU/ml) (J:105024)

• catalase activity in liver (21-28 PU/gm), kidney (6.0-8.7PU/gm), lung (12-17 PU/gm), and intestine (18-19 PU/gm) is lower than wild-type Cat^a mice (J:105024)

• catalase activity in stomach (26 PU/gm) and brain (37-40 PU/gm) is higher than wild-type Cat^a mice (J:105024)

• catalase activity in liver and kidney exhibits increased sensitivity to the inhibitory agents guanidine, urea , and aminotriazole relative to wild-type (J:105024)

• catalase activity in liver and kidney exhibits decreased sensitivity to the inhibitory agent azide relative to wild-type (J:105024)

cellular

abnormal redox activity ( J:105024 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	acatalasia	DOID:2582	OMIM:614097	J:105024

Genotype
MGI:4367478

ht4

• Allelic Composition: Cat^b/Cat⁺
• Genetic Background: Not Specified

homeostasis/metabolism

abnormal catalase activity ( J:5015 )

• blood catalase activity in heterozygotes is generally between 40 and 100 perborate units per ml of whole blood