Phenotypes associated with this allele

• Allele Symbol: Npy1r^tm1Wpg
• Allele Name: targeted mutation 1, William P Gray
• Allele ID: MGI:3053795
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy1r^tm1Wpg/Npy1r^tm1Wpg	involves: 129X1/SvJ * C57BL/6	MGI:3053863
cn2	Npy1r^tm1Wpg/Npy1r^tm1Wpg Tg(Col1a1-cre)2Bek/0	involves: CD-1	MGI:4946407

Genotype
MGI:3053863

hm1

• Allelic Composition: Npy1r^tm1Wpg/Npy1r^tm1Wpg
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:92582 )

• no abnormalities are detected

Genotype
MGI:4946407

cn2

• Allelic Composition: Npy1r^tm1Wpg/Npy1r^tm1Wpg; Tg(Col1a1-cre)2Bek/0
• Genetic Background: involves: CD-1

skeleton

abnormal osteoblast physiology ( J:170291 )

• mice exhibit increased osteoblast activity compared to in wild-type mice

increased diameter of femur ( J:170291 )

• with an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter

increased bone mineral content ( J:170291 )

• whole body and lumbar vertebrae

increased bone mineral density ( J:170291 )

increased bone trabecula number ( J:170291 )

increased trabecular bone thickness ( J:170291 )

abnormal bone ossification ( J:170291 )

• bone formation rate in cancellous and cortical bone is increased compared to in wild-type mice

increased bone strength ( J:170291 )

limbs/digits/tail

increased diameter of femur ( J:170291 )

• with an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter

cellular

abnormal osteoblast physiology ( J:170291 )

• mice exhibit increased osteoblast activity compared to in wild-type mice