Phenotypes associated with this allele

• Allele Symbol: Tg(WapIGFBP3)67Dlr
• Allele Name: transgene insertion 67, Derek LeRoith
• Allele ID: MGI:3053842
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(WapIGFBP3)67Dlr/0	involves: C57BL/6 * SJL	MGI:3800637

Genotype
MGI:3800637

tg1

• Allelic Composition: Tg(WapIGFBP3)67Dlr/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:33047 )

♀ • involution is delayed with fewer apoptotic cells than in wild-type mice

♀ • apoptosis during involution is decreased compared to in wild-type mice

♀ • remodeling during involution is retarded compared to in wild-type mice

mammary gland duct hyperplasia ( J:92578 )

♀ • mice exhibit ductal hypertrophy accompanied by a thickened layer of collagen and extracellular matrix surrounding the flat epithelial cells

abnormal mammary gland alveolus morphology ( J:33047 )

♀ • alveoli are smaller than in wild-type mice

integument

abnormal involution of the mammary gland ( J:33047 )

♀ • involution is delayed with fewer apoptotic cells than in wild-type mice

♀ • apoptosis during involution is decreased compared to in wild-type mice

♀ • remodeling during involution is retarded compared to in wild-type mice

mammary gland duct hyperplasia ( J:92578 )

♀ • mice exhibit ductal hypertrophy accompanied by a thickened layer of collagen and extracellular matrix surrounding the flat epithelial cells

abnormal mammary gland alveolus morphology ( J:33047 )

♀ • alveoli are smaller than in wild-type mice