Phenotypes associated with this allele

• Allele Symbol: Mal^tm1Nsw
• Allele Name: targeted mutation 1, Nicole Shaeren-Wiemers
• Allele ID: MGI:3053860
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mal^tm1Nsw/Mal^tm1Nsw	involves: 129P2/Ola	MGI:3053916

Genotype
MGI:3053916

hm1

• Allelic Composition: Mal^tm1Nsw/Mal^tm1Nsw
• Genetic Background: involves: 129P2/Ola

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Compact myelin of Mal^tm1Nsw/Mal^tm1Nsw mice contains cytoplasmic inclusions

vision/eye

abnormal optic nerve morphology ( J:92517 )

• detached or inverted paranodal loops are seen in most mutants

• transverse bands that mark the paranodal axoglia junction develop normally but become disorganized

• the number of paranodes and juxtaparanodes is reduced and the size of the nodes and paranodes is more variable compared to wild-type mice

nervous system

abnormal optic nerve morphology ( J:92517 )

• detached or inverted paranodal loops are seen in most mutants

• transverse bands that mark the paranodal axoglia junction develop normally but become disorganized

• the number of paranodes and juxtaparanodes is reduced and the size of the nodes and paranodes is more variable compared to wild-type mice

abnormal myelination ( J:92517 )

• the myelin sheath contains cytoplasmic intrusions within the compact myelin and most lack a well-developed periaxonal oligodendrocyte cytoplasmic collar

• some axons appear to be surrounded by more than one myelin sheath