All Phenotypes Gli1<tm3(cre/ERT2)Alj> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli1^{tm3(cre/ERT2)Alj}
targeted mutation 3, Alexandra L Joyner
MGI:3053957

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4461250
cn2	Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tnn^{tm1b(KOMP)Wtsi}/Tnn^{tm1b(KOMP)Wtsi}	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	MGI:6694853
cn3	Gt(ROSA)26Sor^{tm2(HOXC9)Odk}/Gt(ROSA)26Sor^{tm2(HOXC9)Odk} Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺	involves: 129S6/SvEvTac	MGI:5695620
cn4	Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:6197800
cn5	Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3810320
cn6	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:4461251
cn7	Slfn4^{tm1c(EUCOMM)Wtsi}/Slfn4^{tm1c(EUCOMM)Wtsi} Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster	MGI:7531280
cn8	Ar^tm2Ska/Y Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4461249

Allelic Composition	Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm4Wbm mutation (1 available); any Ctnnb1 mutation (49 available)
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal external male genitalia morphology ( J:148515 )

• 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice

• however, development of female genital tracts is normal

abnormal foreskin morphology ( J:148515 )

• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

renal/urinary system

abnormal foreskin morphology ( J:148515 )

• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

Allelic Composition	Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tnn^{tm1b(KOMP)Wtsi}/Tnn^{tm1b(KOMP)Wtsi}
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Tnn^{tm1b(KOMP)Wtsi} mutation (0 available); any Tnn mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

growth/size/body

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

skeleton

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

Allelic Composition	Gt(ROSA)26Sor^{tm2(HOXC9)Odk}/Gt(ROSA)26Sor^{tm2(HOXC9)Odk} Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)
Gt(ROSA)26Sor^{tm2(HOXC9)Odk} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:201472 )

N	• size of the labial cervical loop at the proximal end of the incisor is not affected after tamoxifen injection

Allelic Composition	Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:264185 )

N	• tamoxifen-treated mice do not exhibit distal airspace morphological changes

Allelic Composition	Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:139574 )

• mice survive 45 days

neoplasm

increased medulloblastoma incidence ( J:139574 )

• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days

nervous system

increased medulloblastoma incidence ( J:139574 )

• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal external female genitalia morphology ( J:148515 )

• female tamoxifen-treated mice exhibit well-developed prepuce unlike wild-type female mice

• adult tamoxifen-treated mice exhibit a hyperplasic prepuce with enlarged external genitalia similar to male mice unlike wild-type female mice

• however, the scrotal/perineal region is normal

Allelic Composition	Slfn4^{tm1c(EUCOMM)Wtsi}/Slfn4^{tm1c(EUCOMM)Wtsi} Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster
Cell Lines	EPD0746_4_G08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)
Slfn4^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Slfn4 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:337060 )

• at 4 months after inoculation with Helicobacter felis (H. felis), tamoxifen-treated mice develop significantly less Helicobacter-induced spasmolytic polypeptide-expressing metaplasia (SPEM) than 4-month-infected wild-type controls, as shown by reduced GSII-lectin staining and recovery of some H⁺, K⁺ -ATPase⁺ parietal cells

immune system

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )

• H. felis-infected tamoxifen-treated mice show an increased population of CD8⁺ cytotoxic T cells in the stomach relative to infected wild-type controls

abnormal interleukin level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls

abnormal tumor necrosis factor level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

decreased susceptibility to bacterial infection ( J:337060 )

• H. felis-infected tamoxifen-treated mice show attenuated Helicobacter-induced gastric metaplasia relative to infected wild-type controls

homeostasis/metabolism

abnormal interleukin level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls

abnormal tumor necrosis factor level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

hematopoietic system

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )

• H. felis-infected tamoxifen-treated mice show an increased population of CD8⁺ cytotoxic T cells in the stomach relative to infected wild-type controls

Allelic Composition	Ar^tm2Ska/Y Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (23 available)
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal external male genitalia morphology ( J:148515 )

• tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice

• external genitalis of tamoxifen-treated mice are feminized

abnormal foreskin morphology ( J:148515 )

• underdeveloped in tamoxifen-treated mice

abnormal reproductive system development ( J:148515 )

• prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice

• however, development of internal reproductive organs are normally in tamoxifen-treated mice

renal/urinary system

abnormal foreskin morphology ( J:148515 )

• underdeveloped in tamoxifen-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24