All Phenotypes Shh<tm1(EGFP/cre)Cjt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shh^{tm1(EGFP/cre)Cjt}
targeted mutation 1, Clifford J Tabin
MGI:3053959

Summary

34 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shh^{tm1(EGFP/cre)Cjt}/Shh^{tm1(EGFP/cre)Cjt}	Not Specified	MGI:3054015
cn2	Shh^{tm1(EGFP/cre)Cjt}/Shh^tm2Amc	involves: 129/Sv * C57BL/6J * SWR	MGI:3513051
cn3	Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Sox9^tm2Crm/Sox9^tm2Crm	B6.Cg-Shh^{tm1(EGFP/cre)Cjt} Sox9^tm2Crm	MGI:6378814
cn4	Dicer1^tm1Bdh/Dicer1^tm1Bdh Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129	MGI:4943703
cn5	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129	MGI:5522668
cn6	Dicer1^tm1Bdh/Dicer1⁺ Yy1^tm2.1Yshi/Yy1⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5902326
cn7	Dicer1^tm1Mmk/Dicer1^tm1Mmk Fgf9^tm1.1Fwan/Fgf9^tm1.1Fwan Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129 * 129S4/SvJaeSor * C57BL/6J	MGI:5751753
cn8	Dicer1^tm1Mmk/Dicer1^tm1Mmk Fgf9^tm1.1Fwan/Fgf9⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129 * 129S4/SvJaeSor * C57BL/6J	MGI:5751752
cn9	Dicer1^tm1Mmk/Dicer1^tm1Mmk Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129 * C57BL/6J	MGI:5751748
cn10	Sox9^tm1Gsr/Sox9^tm1Gsr Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129P2/OlaHsd	MGI:5557988
cn11	Ift88^tm1Bky/Ift88^tm1Bky Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129P2/OlaHsd	MGI:6378813
cn12	Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/0	involves: 129S1/Sv	MGI:5588383
cn13	Sp8^tm1Smb/Sp8^tm1Smb Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:7437679
cn14	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:4361162
cn15	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2^tm1Dor Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5694226
cn16	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Gt(ROSA)26Sor^tm1(Fgf8)Lma/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5694211
cn17	Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan}/Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy} Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5557985
cn18	Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5433105
cn19	Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5433106
cn20	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S1/SvlmJ * 129S6/SvEvTac * C57BL/6J * SJL/J	MGI:7518701
cn21	E2f4^tm2.1Lees/E2f4^tm2.1Lees Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	MGI:5904347
cn22	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S4/SvJae * C57BL/6J	MGI:5902322
cn23	Fgfr1^tm3.1Cxd/Fgfr1^tm3.2Cxd Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S6/SvEvTac	MGI:3607119
cn24	Fgfr1^tm3.2Cxd/Fgfr1^tm3.2Cxd Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S6/SvEvTac	MGI:3606229
cn25	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S6/SvEvTac * C57BL/6N	MGI:5495282
cn26	Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Shh^{tm1(EGFP/cre)Cjt}/?	involves: 129S7/SvEvBrd	MGI:5305710
cn27	Disp1^tm2.1Amc/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129/Sv * C57BL/6J * SWR	MGI:3513044
cn28	Disp1^icb/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129/Sv * C57BL/6J * SWR	MGI:3513048
cn29	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129X1/SvJ	MGI:5544581
cn30	Disp1^icb/Disp1^tm1Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129X1/SvJ * C57BL/6J	MGI:3054017
cn31	Gt(ROSA)26Sor^{tm4(CAG-lacZ,-EGFP)Dym}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: C57BL/6	MGI:3777639
cn32	Gt(ROSA)26Sor^{tm1(CAG-Bmpr1a)Que}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/?	Not Specified	MGI:5305711
cn33	Gt(ROSA)26Sor^tm2(Sp8)Lma/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	Not Specified	MGI:5694220
cx34	Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Sox17^tm1Ysk/Sox17⁺	involves: 129S1/Sv * C57BL/6	MGI:6113949

Allelic Composition	Shh^{tm1(EGFP/cre)Cjt}/Shh^{tm1(EGFP/cre)Cjt}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal pulmonary artery morphology ( J:204743 )

• pulmonary arteries connect to aorta instead of the ouflow tract

abnormal vasculogenesis ( J:204743 )

• embryos have a disorganized vascular endothelial plexus along anterior foregut which does not connect to heart inflow and outflow tracts

abnormal vascular smooth muscle morphology ( J:204743 )

• reduction in vascular and airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is detected

absent pulmonary vein ( J:204743 )

• pulmonary veins from left atrium to lung are absent

abnormal atrium myocardium morphology ( J:204743 )

• mutants show reduced muscular development in dorsal wall of atria

abnormal heart left atrium morphology ( J:204743 )

endocrine/exocrine glands

abnormal cystic duct morphology ( J:241569 )

• shortened cystic duct at E14.5

small gallbladder ( J:241569 )

• shortened gallbladder at E14.5

• however, the gallbladder epithelium is histologically normal

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is delayed and defective

muscle

abnormal vascular smooth muscle morphology ( J:204743 )

• reduction in vascular and airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is detected

abnormal atrium myocardium morphology ( J:204743 )

• mutants show reduced muscular development in dorsal wall of atria

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is delayed and defective

growth/size/body

acephaly ( J:241569 )

• fetuses are headless

liver/biliary system

abnormal cystic duct morphology ( J:241569 )

• shortened cystic duct at E14.5

small gallbladder ( J:241569 )

• shortened gallbladder at E14.5

• however, the gallbladder epithelium is histologically normal

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is delayed and defective

abnormal liver development ( J:241569 )

• fetuses exhibit severe growth retardation in the liver without signs of hepatic inflammation

limbs/digits/tail

abnormal limb bone morphology ( J:92504 )

• a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen

skeleton

abnormal limb bone morphology ( J:92504 )

• a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen

respiratory system

abnormal respiratory conducting tube morphology ( J:204743 )

• airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is significantly reduced; airway smooth muscle development is reduced

Allelic Composition	Shh^{tm1(EGFP/cre)Cjt}/Shh^tm2Amc
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Shh^tm2Amc mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cyclopia ( J:94270 )

• homozygous mutants have a cyclopic head similar to Shh null mutants

nervous system

abnormal neural tube morphology ( J:94270 )

• ventral neural tube patterning defects are seen

embryo

abnormal neural tube morphology ( J:94270 )

• ventral neural tube patterning defects are seen

Allelic Composition	Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Sox9^tm2Crm/Sox9^tm2Crm
Genetic Background	B6.Cg-Shh^{tm1(EGFP/cre)Cjt} Sox9^tm2Crm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Sox9^tm2Crm mutation (1 available); any Sox9 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal primitive urogenital sinus morphology ( J:281428 )

• prostatic bud initiation from the urogenital sinus epithelium is unaffected, but buds fail to elongate

Allelic Composition	Dicer1^tm1Bdh/Dicer1^tm1Bdh Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Bdh mutation (4 available); any Dicer1 mutation (96 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:106072 )

• mice die at birth

respiratory system

abnormal lung development ( J:106072 )

• at E12.5, fewer branches are observed and the distal tips of the newly formed branches appear dilated

• the number of dilated branching tips observed at E12.5 corresponds to the number of large, fluid-filled sacs seen at E15.5

• defective branching morphogenesis occurs prior to the increased cell death seen in the distal epithelium at E13.0

• at E11.75, expression of Fgf10 (a key gene involved in lung development) is already up-regulated and expanded in the mesenchyme of mutant lungs

abnormal lung epithelium morphology ( J:106072 )

• at E15.5, mutant lung epithelial cells form large, fluid-filled sacs within each lobe, indicating a severe branching defect

• at E15.5, the mutant epithelium is often detached from the mesenchyme, unlike in control lungs

• at E12.25, increased epithelial cell death is ectopically observed in the secondary bronchi of mutant lungs in addition to the normal pattern of cell death seen in the trachea and primary bronchi

• at E12.5 and E12.75, intense epithelial cell death is prolonged in the mutant trachea and bronchi, unlike in control and wild type lungs

• by E13.0, aberrant cell death is observed in the entire mutant lung epithelium, including the distal branching region, but not in the mesenchyme

small lung lobe ( J:106072 )

• after E13.5, each mutant lung lobe is proportionally smaller than that in control lungs

• however, each lobe maintains a normal shape, indicating a normal lobation pattern

Allelic Composition	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^tm1Matl mutation (2 available); any Robo1 mutation (87 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:193400 )

• normal organ position, diaphragm formation and lung inflation

Allelic Composition	Dicer1^tm1Bdh/Dicer1⁺ Yy1^tm2.1Yshi/Yy1⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:239777 )

N	• embryos do not present lung defects

Allelic Composition	Dicer1^tm1Mmk/Dicer1^tm1Mmk Fgf9^tm1.1Fwan/Fgf9^tm1.1Fwan Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129 * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Mmk mutation (0 available); any Dicer1 mutation (96 available)
Fgf9^tm1.1Fwan mutation (1 available); any Fgf9 mutation (17 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:224791 )

N	• mice show rescue of the lung phenotypes seen in single conditional Dicer1 mutants, showing smaller lungs with reduced cystic dilation of epithelial ducts

Allelic Composition	Dicer1^tm1Mmk/Dicer1^tm1Mmk Fgf9^tm1.1Fwan/Fgf9⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129 * 129S4/SvJaeSor * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:224791 )

N	• mice show rescue of the lung phenotypes seen in single conditional Dicer1 mutants, showing smaller lungs, reduced epithelial dilation, mesenchymal thickness and mesenchymal proliferation

Allelic Composition	Dicer1^tm1Mmk/Dicer1^tm1Mmk Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Mmk mutation (0 available); any Dicer1 mutation (96 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

increased mesenchymal cell proliferation involved in lung development ( J:224791 )

• E12.5 lungs show increased mesenchymal proliferation

lung cyst ( J:224791 )

• E14.5 and E16.5 lungs show cystic expansion of the epithelial ducts

enlarged lung ( J:224791 )

• lungs are larger at E12.5 but are similar in size to controls at E14.5 and E16.5

abnormal branching involved in lung morphogenesis ( J:224791 )

• E12.5, E14.5, and E16.5 lungs exhibit reduced branching

abnormal lung-associated mesenchyme development ( J:224791 )

• E12.5 lungs exhibit expanded mesenchyme

abnormal lung epithelium morphology ( J:224791 )

• E12.5 lungs exhibit dilated epithelial ducts

• E14.5 and E16.5 lungs show cystic expansion of the epithelial ducts

cellular

increased mesenchymal cell proliferation involved in lung development ( J:224791 )

• E12.5 lungs show increased mesenchymal proliferation

growth/size/body

lung cyst ( J:224791 )

• E14.5 and E16.5 lungs show cystic expansion of the epithelial ducts

enlarged lung ( J:224791 )

• lungs are larger at E12.5 but are similar in size to controls at E14.5 and E16.5

Allelic Composition	Sox9^tm1Gsr/Sox9^tm1Gsr Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Sox9^tm1Gsr mutation (2 available); any Sox9 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:202984 )

• the 2 pups that survived past birth had to be euthanized by P7

perinatal lethality, incomplete penetrance ( J:202984 )

• 1 of 3 pups died at birth

respiratory system

lung cyst ( J:202984 )

• develop large, cyst-like structures at the distal epithelial branch tips that are the result of larger, rounder branch tips

abnormal branching involved in lung morphogenesis ( J:202984 )

• cultured lungs from E12.5 embryos show a significant reduction in branching

• branch tips are larger and rounder and lead to large open spaces in the lung

• significant decrease in total lung epithelial cell proliferation at E14.5 resulting from a decrease in proliferation of the distal tip epithelium

abnormal lung epithelium morphology ( J:202984 )

• distal epithelial tips show a range of defects including absence of microvilli, apical membranous blebs and disrupted cell-cell adhesion

• the basal epithelial surface is not uniform and many cells have a rounded appearance with membranous blebs projecting into the subcellular space

• the extracellular matrix and stabilized tubulin appear disrupted at the basal surfaces

small lung ( J:202984 )

• noticeable by E14.5 and more significant by E16.5

respiratory distress ( J:202984 )

• pups that survive birth have difficulty breathing

cellular

abnormal cell differentiation ( J:202984 )

• apparent precocious differentiation of distal tip progenitor cells into type 2 alveolar cells at E14.5

decreased cell migration ( J:202984 )

• migration of epithelial cells from cultured E12.5 lung buds is decreased compared to controls

decreased cell proliferation ( J:202984 )

• significant decrease in total lung epithelial cell proliferation at E14.5 resulting from a decrease in proliferation of the distal tip epithelium

growth/size/body

lung cyst ( J:202984 )

• develop large, cyst-like structures at the distal epithelial branch tips that are the result of larger, rounder branch tips

Allelic Composition	Ift88^tm1Bky/Ift88^tm1Bky Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88^tm1Bky mutation (1 available); any Ift88 mutation (48 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:281425 )

• variable penetrance of highly disorganized palatal rugae. including waved, folded, supernumerary, absence, shortened and fragmented palatal rugae, observed in the intermolar rugae

• no obvious anomalies were found in the antemolar rugae

digestive/alimentary system

abnormal palatal rugae morphology ( J:281425 )

• variable penetrance of highly disorganized palatal rugae. including waved, folded, supernumerary, absence, shortened and fragmented palatal rugae, observed in the intermolar rugae

• no obvious anomalies were found in the antemolar rugae

growth/size/body

abnormal palatal rugae morphology ( J:281425 )

• variable penetrance of highly disorganized palatal rugae. including waved, folded, supernumerary, absence, shortened and fragmented palatal rugae, observed in the intermolar rugae

• no obvious anomalies were found in the antemolar rugae

Allelic Composition	Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/0
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Grem1)Svok} mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:214075 )

• hindlimbs from some E18.5 embryos have multiple posterior distal bifurcations (1/4)

• forelimbs from some E18.5 embryos have large nubs in the posterior (3/4)

postaxial polydactyly ( J:214075 )

• hindlimbs from some E18.5 embryos have posterior polydactyly (3/4)

preaxial polydactyly ( J:214075 )

• forelimbs from some E18.5 embryos have preaxial polydactyly (1/4)

skeleton

polyphalangy ( J:214075 )

• hindlimbs from some E18.5 embryos have multiple posterior distal bifurcations (1/4)

• forelimbs from some E18.5 embryos have large nubs in the posterior (3/4)

Allelic Composition	Sp8^tm1Smb/Sp8^tm1Smb Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Sp8^tm1Smb mutation (0 available); any Sp8 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:200761 )

N	• mice show partial craniofacial rescue of anterior structures; the medial facial prominences partially merge with the lateral and maxillary prominences to form an identifiable snout by E18.5

abnormal craniofacial development ( J:200761 )

• despite partial rescue of anterior structures, the more dorsal structures of the skull and forehead are not rescued

vision/eye

ocular hypertelorism ( J:200761 )

• mice display an inner canthal distance of 5.33 mm +/- 0.26 mm relative to 4.4 mm +/- 0.09 mm for wild-type controls and 6.1 mm +/- 0.45 mm for Sp8^tm1Smb homozygotes with two wild-type Shh alleles, indicating partial rescue of the hypertelorism phenotype

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung development ( J:153098 )

• mice exhibit an expansion of lung endoderm progenitor cells into the stomach unlike in wild-type mice

absent lung buds ( J:153098 )

• mice lack tracheal budding

absent lungs ( J:153098 )

• mice lack lung specification

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2^tm1Dor Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:223057 )

N	• mice exhibit normal early growth, size and shape of genital tubercles

renal/urinary system

abnormal urethra urothelium morphology ( J:223057 )

• abnormal maturation of urethral epithelium

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Gt(ROSA)26Sor^tm1(Fgf8)Lma/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Gt(ROSA)26Sor^tm1(Fgf8)Lma mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:223057 )

N	• a cone-shaped tubercle structure is discernable unlike in urethral epithelium knock-out of beta-catenin

abnormal reproductive system development ( J:223057 )

• mice exhibit failed cloaca septation

limbs/digits/tail

abnormal tail development ( J:223057 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan}/Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy} Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy} mutation (5 available); any Gt(ROSA)26Sor mutation (994 available)
Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung morphology ( J:202984 )

• decrease in airway spaces at E18.5

lung cyst ( J:202984 )

• develop large, cyst-like structures at the distal epithelial branch tips

• cystic buds appear to collapse by E18.5

small lung ( J:202984 )

• noticeable by E14.5 and more significant by E16.5

growth/size/body

lung cyst ( J:202984 )

• develop large, cyst-like structures at the distal epithelial branch tips

• cystic buds appear to collapse by E18.5

Allelic Composition	Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4^tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:185603 )

N	• mice exhibit normal prenatal and postnatal survival

Allelic Composition	Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1^tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4^tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:185603 )

• mice die within minutes of birth of apparent respiratory distress

respiratory system

decreased club cell number ( J:185603 )

• in the proximal airways at E18.5

abnormal respiratory system development ( J:185603 )

• as determined by marker expression, mice exhibit an increase in ciliated epithelial cell differentiation compared with control mice

respiratory distress ( J:185603 )

• at birth

Allelic Composition	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S1/SvlmJ * 129S6/SvEvTac * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7^tm1.1Dmm mutation (1 available); any Chd7 mutation (138 available)
Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze} mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:310063 )

N	• normal hair cells and neurites at P1 in the cochlea

Allelic Composition	E2f4^tm2.1Lees/E2f4^tm2.1Lees Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory motile cilium morphology ( J:241925 )

• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

cellular

abnormal respiratory motile cilium morphology ( J:241925 )

• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium

• however, primary cilia formation occurs

Allelic Composition	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Yy1^tm2.1Yshi mutation (0 available); any Yy1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:239777 )

• all newborns die at birth from respiratory failure

growth/size/body

lung cyst ( J:239777 )

• E18.5 lungs show the presence of dilated fluid-filled sacs

• proliferation assays in lungs from E18.5 fetuses show an increase in cell proliferation in cystic walls

• neither secretory club (Clara) cells or ciliated cells are seen in cyst epithelium at E18.5 and cysts are lined by Type II and Type I pneumocytes

• a microvascular network is present in the parenchyma forming the cyst walls

left pulmonary isomerism ( J:239777 )

• E12.5 lungs show two hypoplastic lobes instead of the expected asymmetric pattern of 4 right lobes and 1 left lobe

respiratory system

increased lung apoptosis ( J:239777 )

• apoptosis is increased in lung mesenchyme at E14.5

• E12.5 embryos cultured in vitro show increased apoptosis in the lung

• the addition of recombinant mouse SHH into the media rescues the increased apoptosis

abnormal lung morphology ( J:239777 )

• E18.5 lungs exhibit a disorganized architecture

lung cyst ( J:239777 )

• E18.5 lungs show the presence of dilated fluid-filled sacs

• proliferation assays in lungs from E18.5 fetuses show an increase in cell proliferation in cystic walls

• neither secretory club (Clara) cells or ciliated cells are seen in cyst epithelium at E18.5 and cysts are lined by Type II and Type I pneumocytes

• a microvascular network is present in the parenchyma forming the cyst walls

left pulmonary isomerism ( J:239777 )

• E12.5 lungs show two hypoplastic lobes instead of the expected asymmetric pattern of 4 right lobes and 1 left lobe

abnormal lung development ( J:239777 )

• marker analysis indicates altered patterning and cell differentiation in the lung

abnormal branching involved in lung morphogenesis ( J:239777 )

• branching morphogenesis in the lung is inhibited, however, distal epithelial cell differentiation is maintained

• E12.5 embryos cultured in vitro fail with branching of lung

• the addition of recombinant mouse SHH into the media does not rescue the branching defect

abnormal lung-associated mesenchyme development ( J:239777 )

• impairment of peribronchial smooth muscle differentiation as indicated by a lack of markers of airway smooth muscle differentiation around cysts

abnormal lung epithelium morphology ( J:239777 )

• lung epithelium exhibits an abnormal stratified structure at E12.5

decreased club cell number ( J:239777 )

• club (Clara) cells are scarce in the proximal airways

abnormal airway basal cell morphology ( J:239777 )

• basal cells are distributed irregularly along the proximal airways of embryos, although the number of basal cells is not altered

decreased respiratory mucosa goblet cell number ( J:239777 )

• goblet cells are scarce in the proximal airways

abnormal trachea morphology ( J:239777 )

• trachea is thinner with disorganized cartilage rings

• trachea is longer

abnormal tracheal ciliated epithelium morphology ( J:239777 )

• ciliated cells are scarce in the airways

abnormal tracheal cartilage morphology ( J:239777 )

• trachea shows abnormal formation of cartilage rings

trachea stenosis ( J:239777 )

respiratory failure ( J:239777 )

abnormal respiratory epithelium physiology ( J:239777 )

• reduction in lung epithelium proliferation at E12.5

cellular

increased lung apoptosis ( J:239777 )

• apoptosis is increased in lung mesenchyme at E14.5

• E12.5 embryos cultured in vitro show increased apoptosis in the lung

• the addition of recombinant mouse SHH into the media rescues the increased apoptosis

impaired myofibroblast differentiation ( J:239777 )

• differentiation of airway myofibroblasts is impaired

skeleton

abnormal tracheal cartilage morphology ( J:239777 )

• trachea shows abnormal formation of cartilage rings

Allelic Composition	Fgfr1^tm3.1Cxd/Fgfr1^tm3.2Cxd Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm3.1Cxd mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1^tm3.2Cxd mutation (0 available); any Fgfr1 mutation (223 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

oligodactyly ( J:101736 )

• at E18.5 a single digit (probably digit 3) is absent on autopods of both the fore and hindlimbs

abnormal embryonic autopod plate morphology ( J:101736 )

• at E11.5, limb bud size is normal but only 4 digit condensations are present and the 2 middle condensations are farther apart than normal

Allelic Composition	Fgfr1^tm3.2Cxd/Fgfr1^tm3.2Cxd Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm3.2Cxd mutation (0 available); any Fgfr1 mutation (223 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

oligodactyly ( J:101736 )

• at E18.5 a single digit (probably digit 3) is absent on autopods of both the fore and hindlimbs

abnormal embryonic autopod plate morphology ( J:101736 )

• at E11.5, limb bud size is normal but only 4 digit condensations are present and the 2 middle condensations are farther apart than normal

Allelic Composition	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Wnt1^tm1.1Mze mutation (0 available); any Wnt1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

premature neuronal precursor differentiation ( J:194842 )

• significant increase of the number of differentiated MbDA neurons at E11.5

• significant increase in the number of Ki67+ progenitors in the differentiating zone in medial planes

abnormal midbrain morphology ( J:194842 )

• depletion of medial MbDA neurons and expansion of more laterally positioned MbDA neurons at E12.5

decreased neuron number ( J:194842 )

• depletion of medial MbDA neurons

cellular

premature neuronal precursor differentiation ( J:194842 )

• significant increase of the number of differentiated MbDA neurons at E11.5

• significant increase in the number of Ki67+ progenitors in the differentiating zone in medial planes

Allelic Composition	Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Shh^{tm1(EGFP/cre)Cjt}/?
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:166768 )

• most homozygotes die in utero or at birth

• some survival to 9 days of age

Allelic Composition	Disp1^tm2.1Amc/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^tm2.1Amc mutation (0 available); any Disp1 mutation (61 available)
Disp1^tm2Amc mutation (1 available); any Disp1 mutation (61 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:94270 )

craniofacial

abnormal parietal bone morphology ( J:94270 )

• ossification of the parietal bone is delayed

absent premaxilla ( J:94270 )

abnormal nasal pit morphology ( J:94270 )

• abnormally close association of the nasal pits

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

skeleton

abnormal parietal bone morphology ( J:94270 )

• ossification of the parietal bone is delayed

absent premaxilla ( J:94270 )

nervous system

abnormal neuron differentiation ( J:94270 )

• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

respiratory system

abnormal nasal pit morphology ( J:94270 )

• abnormally close association of the nasal pits

cellular

abnormal neuron differentiation ( J:94270 )

• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

growth/size/body

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

Allelic Composition	Disp1^icb/Disp1^tm2Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129/Sv * C57BL/6J * SWR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^icb mutation (0 available); any Disp1 mutation (61 available)
Disp1^tm2Amc mutation (1 available); any Disp1 mutation (61 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:94270 )

craniofacial

absent parietal bone ( J:94270 )

absent premaxilla ( J:94270 )

abnormal nasal pit morphology ( J:94270 )

• fusion of the nasal pits

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

skeleton

absent parietal bone ( J:94270 )

absent premaxilla ( J:94270 )

nervous system

abnormal neuron differentiation ( J:94270 )

• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

absent floor plate ( J:94270 )

embryo

absent floor plate ( J:94270 )

respiratory system

abnormal nasal pit morphology ( J:94270 )

• fusion of the nasal pits

cellular

abnormal neuron differentiation ( J:94270 )

• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

growth/size/body

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung vasculature morphology ( J:204743 )

• in absence of lung formation, the pulmonary vascular plexus persists throughout embryonic development, but does not branch or develop further

tracheoesophageal fistula ( J:153098 )

abnormal lung development ( J:204743 )

• lungs fail to develop from the foregut

absent lungs ( J:204743 )

• lung agenesis is found in embryos examined at E13.5 and E17.5

cardiovascular system

cardiovascular system phenotype ( J:204743 )

N	• although no lungs develop, heart development and outflow and inflow tract structures are relatively normal, including atrial septation, septation between aorta and the pulmonary trunk, and atrioventricular canal development

abnormal pulmonary artery morphology ( J:204743 )

• primitive non-branched pulmonary arteries which flank the esophagus and originate from the pulmonary trunk persist in E17.5 embryos

• pulmonary veins and pulmonary arteries develop and intersect at approximate location where a lung bud would be present in a normal embryo

abnormal lung vasculature morphology ( J:204743 )

• in absence of lung formation, the pulmonary vascular plexus persists throughout embryonic development, but does not branch or develop further

abnormal pulmonary vein morphology ( J:204743 )

digestive/alimentary system

tracheoesophageal fistula ( J:153098 )

Allelic Composition	Disp1^icb/Disp1^tm1Amc Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^icb mutation (0 available); any Disp1 mutation (61 available)
Disp1^tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

oligodactyly ( J:92504 )

• digit 2 is absent, all other digits are present

Allelic Composition	Gt(ROSA)26Sor^{tm4(CAG-lacZ,-EGFP)Dym}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(CAG-lacZ,-EGFP)Dym} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:132568 )

• the mean overall thickness of the skin of E18.5 embryos is reduced by 10% compared to wild-type embryos

thin epidermis ( J:132568 )

• the mean thickness of the epidermis of E18.5 embryos is slightly but significantly reduced by 4% compared to wild-type embyros

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmpr1a)Que}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Bmpr1a)Que} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:166768 )

• all heterozygotes die before 5 days of age

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:166768 )

• simple columnar epithelial cells along the esophagus at E15.5, primarily ventrally

abnormal forestomach morphology ( J:166768 )

• scattered appearance of simple columnar epithelium in the forestomach at E15.5 and at birth

Allelic Composition	Gt(ROSA)26Sor^tm2(Sp8)Lma/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(Sp8)Lma mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:223057 )

N	• mice exhibit normal appendage development

Allelic Composition	Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Sox17^tm1Ysk/Sox17⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)
Sox17^tm1Ysk mutation (0 available); any Sox17 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is more severely delayed and defective than in either single mutant

muscle

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is more severely delayed and defective than in either single mutant

liver/biliary system

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is more severely delayed and defective than in either single mutant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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