All Phenotypes Cdk6<tm1Bbd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3054095
cn2	Cdk6^tm1Bbd/Cdk6^tm1Bbd Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844194
cx3	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3723204
cx4	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3054096
cx5	Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR	MGI:3054097

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thymus morphology ( J:92529 )

thymus cortex atrophy ( J:92529 )

• cortical area atrophic

thymus hypoplasia ( J:92529 )

• decreased cellularity

decreased mature ovarian follicle number ( J:92529 )

• 20-25% as many mature follicles as in normal controls

growth/size/body

decreased body weight ( J:92529 )

• females slightly smaller than normal, 15% smaller at 12 weeks of age

hematopoietic system

decreased T cell proliferation ( J:92529 )

• reduced proliferative response in T cells

abnormal hematopoietic system morphology/development ( J:92529 )

abnormal thymus morphology ( J:92529 )

thymus cortex atrophy ( J:92529 )

• cortical area atrophic

thymus hypoplasia ( J:92529 )

• decreased cellularity

abnormal definitive hematopoiesis ( J:92529 )

decreased megakaryocyte cell number ( J:92529 )

• megakaryocytes in spleen reduced to about 1/3 normal

abnormal erythrocyte morphology ( J:92529 )

decreased erythrocyte cell number ( J:92529 )

• peripheral RBC count reduced about 15%

increased mean corpuscular hemoglobin concentration ( J:92529 )

• higher hemoglobin concentration per cell, overall concentration normal

increased mean corpuscular volume ( J:92529 )

increased single-positive T cell number ( J:92529 )

• slight increase in CD4+ and CD8+ single positive cells

decreased leukocyte cell number ( J:92529 )

• some mice with decreased granulocytes, macrophage, neutrophiles or platelets

• peripheral lymphocytes and ratios are normal

abnormal spleen morphology ( J:92529 )

abnormal spleen red pulp morphology ( J:92529 )

• decreased cell density in the red pulp

small spleen ( J:92529 )

spleen hypoplasia ( J:92529 )

• 35-40% of cell in erythroid lineage as opposed to 70-75% normally

immune system

decreased T cell proliferation ( J:92529 )

• reduced proliferative response in T cells

abnormal thymus morphology ( J:92529 )

thymus cortex atrophy ( J:92529 )

• cortical area atrophic

thymus hypoplasia ( J:92529 )

• decreased cellularity

increased single-positive T cell number ( J:92529 )

• slight increase in CD4+ and CD8+ single positive cells

decreased leukocyte cell number ( J:92529 )

• some mice with decreased granulocytes, macrophage, neutrophiles or platelets

• peripheral lymphocytes and ratios are normal

abnormal spleen morphology ( J:92529 )

abnormal spleen red pulp morphology ( J:92529 )

• decreased cell density in the red pulp

small spleen ( J:92529 )

spleen hypoplasia ( J:92529 )

• 35-40% of cell in erythroid lineage as opposed to 70-75% normally

reproductive system

decreased mature ovarian follicle number ( J:92529 )

• 20-25% as many mature follicles as in normal controls

reduced female fertility ( J:92529 )

• 30% of females were sterile

cellular

decreased T cell proliferation ( J:92529 )

• reduced proliferative response in T cells

Allelic Composition	Cdk6^tm1Bbd/Cdk6^tm1Bbd Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (40 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (84 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:161780 )

• 50% of tamoxifen-treated mice survive at 40 weeks

neoplasm

increased adenoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

increased lung non-small cell carcinoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

respiratory system

increased lung non-small cell carcinoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:161780

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)
Cdk4^tm1Bbd mutation (1 available); any Cdk4 mutation (58 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

growth/size/body

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

cardiovascular system

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

thin ventricular wall ( J:124678 )

• ventricular walls are thinner than in wild-type mice due to a decrease in the number of proliferating cardiomyocytes

cellular

decreased cell proliferation ( J:124678 )

• proliferation of mouse embryonic fibroblast cells is partially compromised

• exiting quiescence following serum treatment is delayed

liver/biliary system

liver hypoplasia ( J:124678 )

• between E12.5 and E13.5, livers exhibit a three-fold reduction in cellularity that is not accounted for by the decrease in embryo size

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:124678 )

• common myeloid progenitor cells are reduced 8-fold in number

muscle

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

embryo

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:92529 )

abnormal oogenesis ( J:92529 )

• marked defects in oogenesis seen

abnormal spermatogenesis ( J:92529 )

• marked defects in spermatogenesis seen

infertility ( J:92529 )

• double homozygotes are sterile

cellular

abnormal oogenesis ( J:92529 )

• marked defects in oogenesis seen

Allelic Composition	Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm1Bbd mutation (1 available); any Cdk4 mutation (58 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:92529 )

• of the few homozygotes to be born alive, all were dead within a few hours of birth

lethality throughout fetal growth and development, incomplete penetrance ( J:92529 )

• 25% of homozygotes are dead by E14.5

• 50% dead by E18.5

embryo

decreased embryo size ( J:92529 )

• embryos well formed but small

growth/size/body

decreased embryo size ( J:92529 )

• embryos well formed but small

hematopoietic system

extramedullary hematopoiesis ( J:92529 )

• decreased numbers of erythroid precursors in the liver and few in proliferative stage

• lymphoid and myeloid lineage reductions are disproportionate

• proliferative potential of all stem cells is severely reduced

abnormal erythrocyte morphology ( J:92529 )

• RBCs are megaloblastic in appearance

decreased erythrocyte cell number ( J:92529 )

• decreased peripheral RBC counts

decreased hematopoietic stem cell number ( J:92529 )

• hematopoietic stem cell numbers reduced in proportion to reduced cellularity

liver/biliary system

liver hypoplasia ( J:92529 )

• small livers with significantly reduced cellularity by E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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